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path(HM:"Oxidative damage")

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Entity

Name
Oxidative damage
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:heme) increases path(HM:"Oxidative damage") View Subject | View Object

These novel data support a role for A1M in the protection against oxidative damage due to extracellular Hb and heme in the joint in various knee arthropathies. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:HBB) increases path(HM:"Oxidative damage") View Subject | View Object

These novel data support a role for A1M in the protection against oxidative damage due to extracellular Hb and heme in the joint in various knee arthropathies. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(HM:"Oxidative damage") View Subject | View Object

Of particular interest for this investigation is that the expression of A1M has been shown to be up-regulated in several cells and tissues during oxidative stress conditions in response to elevated levels of ROS, Hb, and free heme (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

When adjusted for their respective absolute concentrations, the higher the proportion sf-A1M to sf-heme or sf-Hb, the less oxidative damage measured as protein carbonyl groups in synovial fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

These novel data support a role for A1M in the protection against oxidative damage due to extracellular Hb and heme in the joint in various knee arthropathies. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:Hemorrhage) increases path(HM:"Oxidative damage") View Subject | View Object

In serum, the A1M concentration in the AIA group was between 1.3- and 1.4-fold higher compared to the injury and osteoarthritis groups (p = 0.035 and 0.030, respectively), whereas the 1.2-fold higher mean concentration compared to the reference group was not statistically significan (p = 0.15; Figure 1A). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Results

Out-Edges 1

path(HM:"Oxidative damage") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Of particular interest for this investigation is that the expression of A1M has been shown to be up-regulated in several cells and tissues during oxidative stress conditions in response to elevated levels of ROS, Hb, and free heme (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.