Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Wound Healing") View Subject | View Object

In addition to the obvious protective benefit of exogenous A1M binding and neutralizing cell-free Hb and heme, it may also be beneficial as a repair mechanism in already damaged cartilage, since in vitro studies showed that collagen fibrils were restored to normal by addition of recombinant A1M after destruction already had begun (Olsson et al., 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:HMOX1) increases bp(MESH:"Wound Healing") View Subject | View Object

During the resolution phase of inflammation HO-1 expression in leukocytes reduces adhesion molecules expression and leukocytes migration, thus contributing to wound healing (Wagener et al., 2003a). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

Out-Edges 1

bp(MESH:"Wound Healing") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

In addition to the obvious protective benefit of exogenous A1M binding and neutralizing cell-free Hb and heme, it may also be beneficial as a repair mechanism in already damaged cartilage, since in vitro studies showed that collagen fibrils were restored to normal by addition of recombinant A1M after destruction already had begun (Olsson et al., 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.