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a(MESH:"Lymphatic Vessels")

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Entity

Name
Lymphatic Vessels
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 1

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

In-Edges 24

a(CHEBI:"amyloid-beta") negativeCorrelation act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Analysis of lymphoid and myeloid cell populations in the meninges (Extended Data Fig. 9d) demonstrated a significant increase in the number of macrophages upon lymphatic ablation compared to both control groups (Extended Data Fig. 9e), which might be correlated with increased amyloid-β deposition and inflammation in the meninges PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Brain
MeSH
Cerebrospinal Fluid

a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") View Subject | View Object

The use of this method resulted in effective ablation of meningeal lymphatic vessels (Fig. 1b, c), without any detectable off-target effects in the coverage of meningeal blood vasculature seven days after the procedure (Fig. 1d) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

A significant reduction in OVA-A647 drainage was observed in the visudyne with photoconversion group compared to the control groups (Extended Data Fig. 1b) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

However, significant differences in hippocampal gene expression were found in response to MWM performance after prolonged meningeal lymphatic ablation (Extended Data Fig. 5m, n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Meninges

bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus

bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Ageing also leads to progressive lymphatic vessel dysfunction in peripheral tissues PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

The reported findings that ageing is also associated with peripheral lymphatic dysfunction led us to hypothesize that the deterioration of meningeal lymphatic vessels underlies some aspects of age-associated cognitive decline PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Impaired brain perfusion by CSF in old mice was accompanied by a decrease in meningeal lymphatic vessel diameter and coverage, as well as decreased drainage of CSF macromolecules into dCLNs in both females and males (Extended Data Fig. 6c–f) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Transcranial delivery (through a thinned skull surface) of hydrogel-encapsulated VEGF-C peptide also resulted in increased diameter of meningeal lymphatics in young and old mice (Extended Data Fig. 7a–c) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

We have previously shown that treatment with recombinant VEGF-C increases the diameter of meningeal lymphatic vessels PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Furthermore, delivery of VEGF-C by adenoviral gene therapy was previously found to efficiently boost peripheral lymphatic sprouting and function PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of young mice with AAV1-CM-mVEGF-C resulted in a significant increase in meningeal lymphatic vessel diameter, without affecting blood vessel coverage (Extended Data Fig. 6k–m) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of old mice (at 20–24 months) with AAV1-CMV-mVEGF-C also resulted in increased lymphatic vessel diameter (compared to AAV1-CMV-eGFP) without detectable off-target effects on the meningeal blood vasculature coverage and on meningeal and/or brain vascular haemodynamics (Fig. 2e–h and Extended Data Fig. 6n–p) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

This VEGF-C treatment led to a significant increase in the function of meningeal lymphatic vessels in old mice, whereas young–adult mice did not respond to the treatment (Extended Data Fig. 7d, e), probably due to the ceiling effect of their existing capacity to drain OVA-A647 PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") View Subject | View Object

Moreover, viral expression of mVEGF-C did not significantly affect the diameter of meningeal lymphatic vessels, the level of amyloid-β in the CSF, or amyloid-β deposition in the hippocampus (Extended Data Fig. 8g–n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges
MeSH
Alzheimer Disease

p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment with VEGF-C156S resulted in a significant increase in meningeal lymphatic diameter (Extended Data Fig. 7i, j), drainage of tracer from the CSF (Extended Data Fig. 7k, l), and paravascular influx of tracer into the brains of old mice (Extended Data Fig. 7m, n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Analysis of lymphoid and myeloid cell populations in the meninges (Extended Data Fig. 9d) demonstrated a significant increase in the number of macrophages upon lymphatic ablation compared to both control groups (Extended Data Fig. 9e), which might be correlated with increased amyloid-β deposition and inflammation in the meninges PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

Out-Edges 40

a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) View Subject | View Object

Here we show that meningeal lymphatic vessels have an essential role in maintaining brain homeostasis by draining macromolecules from the CNS (both CSF and ISF) into the cervical lymph nodes PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Meninges

a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) View Subject | View Object

Here we show that meningeal lymphatic vessels have an essential role in maintaining brain homeostasis by draining macromolecules from the CNS (both CSF and ISF) into the cervical lymph nodes PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges
MeSH
Neck

act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Brain
MeSH
Cerebrospinal Fluid

act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) View Subject | View Object

These findings, as has been suggested previously, demonstrate that the efflux of parenchymal and/or ISF macromolecules and the drainage of these macromolecules into dCLNs are impaired as a consequence of meningeal lymphatic ablation, thus functionally connecting meningeal lymphatics with CSF influx and ISF efflux mechanisms PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges
MeSH
Neck

act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) View Subject | View Object

These findings, as has been suggested previously, demonstrate that the efflux of parenchymal and/or ISF macromolecules and the drainage of these macromolecules into dCLNs are impaired as a consequence of meningeal lymphatic ablation, thus functionally connecting meningeal lymphatics with CSF influx and ISF efflux mechanisms PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges
MeSH
Neck

act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) View Subject | View Object

Notably, the rate of tracer influx into the brain parenchyma was significantly increased as a result of enhanced meningeal lymphatic function (Fig. 2k, l and Extended Data Fig. 6q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Similar findings for brain perfusion by CSF were observed when meningeal lymphatic drainage was disrupted by surgical ligation of the vessels afferent to the dCLNs (Extended Data Fig. 3a–d) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Prospero homeobox protein 1 heterozygous (Prox1+/−) mice, a genetic model of lymphatic vessel malfunction25, also presented impaired perfusion through the brain parenchyma and impaired CSF drainage (Extended Data Fig. 3e–i) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") View Subject | View Object

Prospero homeobox protein 1 heterozygous (Prox1+/−) mice, a genetic model of lymphatic vessel malfunction25, also presented impaired perfusion through the brain parenchyma and impaired CSF drainage (Extended Data Fig. 3e–i) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Parenchymal Tissue

act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) View Subject | View Object

Notably, along with the lower influx of Gd into the parenchyma, we observed higher contrast in signal intensity (over approximately 52 min) in the ventricles of visudyne-treated mice, suggesting that Gd accumulation in the CSF occurred (Extended Data Fig. 3n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") View Subject | View Object

A significant difference between control groups and visudyne with photoconversion group was observed in the cued test of the CFC (Extended Data Fig. 5e, f), which points to an impairment in fear memory and in hippocampal– amygdala neuronal circuitry in mice with impaired meningeal lymphatic vessel function PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") View Subject | View Object

Mice with ablated meningeal lymphatic vessels also showed significant deficits in spatial learning in the MWM (Fig. 1k–o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") View Subject | View Object

Similar impairments in spatial learning and memory were observed in mice that had undergone lymphatic ligation (Extended Data Fig. 5g–j), supporting the notion that the observed effect is a result of dysfunctional meningeal lymphatic drainage and not an artefact of the ablation method using visudyne PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) View Subject | View Object

Similar impairments in spatial learning and memory were observed in mice that had undergone lymphatic ligation (Extended Data Fig. 5g–j), supporting the notion that the observed effect is a result of dysfunctional meningeal lymphatic drainage and not an artefact of the ablation method using visudyne PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") View Subject | View Object

However, significant differences in hippocampal gene expression were found in response to MWM performance after prolonged meningeal lymphatic ablation (Extended Data Fig. 5m, n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") View Subject | View Object

Notably, although the fold change in significantly altered genes after lymphatic ablation and MWM was moderate (−1.79 < log2(fold change) < 1.69), functional enrichment analysis (Extended Data Fig. 5o, p) revealed changes in gene sets associated with neurodegenerative diseases, such as Huntington’s, Parkinson’s and Alzheimer’s disease (Extended Data Fig. 5o) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus

act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
MeSH
Mitochondria
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) View Subject | View Object

The reported findings that ageing is also associated with peripheral lymphatic dysfunction led us to hypothesize that the deterioration of meningeal lymphatic vessels underlies some aspects of age-associated cognitive decline PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) View Subject | View Object

Collectively, these data point to no apparent meningeal lymphatic dysfunction in transgenic mice with Alzheimer’s disease at younger ages, which might explain the inefficacy of mVEGF-C treatment PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges
MeSH
Alzheimer Disease

act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

However, 5xFAD mice with ablated meningeal lymphatic vessels demonstrated marked deposition of amyloid-β in the meninges (Fig. 3b), as well as macrophage recruitment to large amyloid-β aggregates (Fig. 3c) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:"amyloid-beta") View Subject | View Object

Analysis of lymphoid and myeloid cell populations in the meninges (Extended Data Fig. 9d) demonstrated a significant increase in the number of macrophages upon lymphatic ablation compared to both control groups (Extended Data Fig. 9e), which might be correlated with increased amyloid-β deposition and inflammation in the meninges PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Notably, along with meningeal amyloid-β pathology, we observed an aggravation of brain amyloid-β burden in the hippocampi of 5xFAD mice with dysfunctional meningeal lymphatic vessels (Fig. 3d–g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

A similar outcome was observed in J20 transgenic mice after a total of three months of meningeal lymphatic ablation (Extended Data Fig. 9f); amyloid-β aggregates had formed in the meninges (Extended Data Fig. 9g) and the amyloid-β plaque load in the hippocampi of these mice was significantly increased (Extended Data Fig. 9h–k) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

a(MESH:"Lymphatic Vessels") decreases a(CHEBI:"amyloid-beta") View Subject | View Object

These findings showed that prominent meningeal amyloid-β deposition observed in patients with Alzheimer’s disease is also observed in mouse models of Alzheimer’s disease after meningeal lymphatic vessel ablation PubMed:30046111

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Meninges
MeSH
Alzheimer Disease

act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") View Subject | View Object

However, 5xFAD mice with ablated meningeal lymphatic vessels demonstrated marked deposition of amyloid-β in the meninges (Fig. 3b), as well as macrophage recruitment to large amyloid-β aggregates (Fig. 3c) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) View Subject | View Object

Analysis of lymphoid and myeloid cell populations in the meninges (Extended Data Fig. 9d) demonstrated a significant increase in the number of macrophages upon lymphatic ablation compared to both control groups (Extended Data Fig. 9e), which might be correlated with increased amyloid-β deposition and inflammation in the meninges PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) View Subject | View Object

Analysis of lymphoid and myeloid cell populations in the meninges (Extended Data Fig. 9d) demonstrated a significant increase in the number of macrophages upon lymphatic ablation compared to both control groups (Extended Data Fig. 9e), which might be correlated with increased amyloid-β deposition and inflammation in the meninges PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) decreases a(HBP:HBP00018) View Subject | View Object

A similar outcome was observed in J20 transgenic mice after a total of three months of meningeal lymphatic ablation (Extended Data Fig. 9f); amyloid-β aggregates had formed in the meninges (Extended Data Fig. 9g) and the amyloid-β plaque load in the hippocampi of these mice was significantly increased (Extended Data Fig. 9h–k) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.