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Mitochondria

Name
Mitochondria
Namespace Keyword
CellStructure
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-structure/cell-structure-20170511.belanno

Sample Annotated Edges 5

act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
MeSH
Mitochondria
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

a(PUBCHEM:64627) decreases a(MESH:Axons) View Subject | View Object

The axonal density of mitochondria, which is slightly lower in proaggregant compared with antiaggregant Tau transgenic slices, is marginally decreased by 64627 treatment albeit in a genotype-independent manner (Fig. S7) PubMed:27671637

Appears in Networks:
Annotations
MeSH
Mitochondria

Showing 5 of 17 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.