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bp(MESH:"Cerebrovascular Circulation")

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Entity

Name
Cerebrovascular Circulation
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 2

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

In-Edges 10

a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Brain perfusion by the CSF tracer was found to be significantly lower in the visudyne with photoconversion group than in the control groups (Fig. 1e, f and Extended Data Fig. 2f, g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Similar findings for brain perfusion by CSF were observed when meningeal lymphatic drainage was disrupted by surgical ligation of the vessels afferent to the dCLNs (Extended Data Fig. 3a–d) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Prospero homeobox protein 1 heterozygous (Prox1+/−) mice, a genetic model of lymphatic vessel malfunction25, also presented impaired perfusion through the brain parenchyma and impaired CSF drainage (Extended Data Fig. 3e–i) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

DQ improved cerebral blood flow in tauNFT Mapt0/0 mice such that cerebral blood flow was no longer statistically different from controls (Figure S5d, e) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Tauopathies

p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

In brain tissue with tau pathology, cerebral blood flow was elevated in tauNFT Mapt0/0 vehicle-treated mice (21% whole brain, P = 0.045; cortex, 48.7%, P = 0.051, Figure S5d, e), and consistent with previous reports of tauNFT mice on a Mapt+/+ background (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Tauopathies

path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 7

bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Impaired brain perfusion by CSF in old mice was accompanied by a decrease in meningeal lymphatic vessel diameter and coverage, as well as decreased drainage of CSF macromolecules into dCLNs in both females and males (Extended Data Fig. 6c–f) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Impaired brain perfusion by CSF in old mice was accompanied by a decrease in meningeal lymphatic vessel diameter and coverage, as well as decreased drainage of CSF macromolecules into dCLNs in both females and males (Extended Data Fig. 6c–f) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebrospinal Fluid

bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") View Subject | View Object

Aberrant cerebral blood flow is a functional defect that occurs in AD and tauNFT mice, and is closely associated with cognitive impairment (Wells et al., 2015) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.