Namespace Keyword
Namespace Version
Namespace URL

Sample Annotated Edges 5

act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules PubMed:30046111

p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") View Subject | View Object

Moreover, viral expression of mVEGF-C did not significantly affect the diameter of meningeal lymphatic vessels, the level of amyloid-β in the CSF, or amyloid-β deposition in the hippocampus (Extended Data Fig. 8g–n) PubMed:30046111

act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) View Subject | View Object

Notably, along with the lower influx of Gd into the parenchyma, we observed higher contrast in signal intensity (over approximately 52 min) in the ventricles of visudyne-treated mice, suggesting that Gd accumulation in the CSF occurred (Extended Data Fig. 3n) PubMed:30046111

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of young mice with AAV1-CM-mVEGF-C resulted in a significant increase in meningeal lymphatic vessel diameter, without affecting blood vessel coverage (Extended Data Fig. 6k–m) PubMed:30046111

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of old mice (at 20–24 months) with AAV1-CMV-mVEGF-C also resulted in increased lymphatic vessel diameter (compared to AAV1-CMV-eGFP) without detectable off-target effects on the meningeal blood vasculature coverage and on meningeal and/or brain vascular haemodynamics (Fig. 2e–h and Extended Data Fig. 6n–p) PubMed:30046111


BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.