1. Catalog
  2. Nodes
  3. p(MGI:Vegfc)

p(MGI:Vegfc)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Vegfc
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 1

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

In-Edges 2

act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) View Subject | View Object

Collectively, these data point to no apparent meningeal lymphatic dysfunction in transgenic mice with Alzheimer’s disease at younger ages, which might explain the inefficacy of mVEGF-C treatment PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges
MeSH
Alzheimer Disease

composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) hasComponent p(MGI:Vegfc) View Subject | View Object

Appears in Networks:

Out-Edges 14

p(MGI:Vegfc) hasVariant p(MGI:Vegfc, var("p.Cys156Ser")) View Subject | View Object

Appears in Networks:

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

We have previously shown that treatment with recombinant VEGF-C increases the diameter of meningeal lymphatic vessels PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Furthermore, delivery of VEGF-C by adenoviral gene therapy was previously found to efficiently boost peripheral lymphatic sprouting and function PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of young mice with AAV1-CM-mVEGF-C resulted in a significant increase in meningeal lymphatic vessel diameter, without affecting blood vessel coverage (Extended Data Fig. 6k–m) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") View Subject | View Object

Treatment of old mice (at 20–24 months) with AAV1-CMV-mVEGF-C also resulted in increased lymphatic vessel diameter (compared to AAV1-CMV-eGFP) without detectable off-target effects on the meningeal blood vasculature coverage and on meningeal and/or brain vascular haemodynamics (Fig. 2e–h and Extended Data Fig. 6n–p) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges

p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

This VEGF-C treatment led to a significant increase in the function of meningeal lymphatic vessels in old mice, whereas young–adult mice did not respond to the treatment (Extended Data Fig. 7d, e), probably due to the ceiling effect of their existing capacity to drain OVA-A647 PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") View Subject | View Object

Moreover, viral expression of mVEGF-C did not significantly affect the diameter of meningeal lymphatic vessels, the level of amyloid-β in the CSF, or amyloid-β deposition in the hippocampus (Extended Data Fig. 8g–n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Low
MeSH
Meninges
MeSH
Alzheimer Disease

p(MGI:Vegfc) increases path(MESH:"Spatial Learning") View Subject | View Object

However, AAV1-CMV-mVEGF-C treatment resulted in significant improvement in the latency to platform and in the percentage of allocentric navigation strategies, in the MWM reversal at 12–14 months (Extended Data Fig. 7q, t) and in the MWM acquisition and reversal at 20–22 months (Extended Data Fig. 7r, u), compared to AAV1-CMV-eGFP-treated age-matched mice PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") View Subject | View Object

Increased expression of VEGF-C in the adult brain has previously been shown to boost proliferation of neural stem cells in the hippocampus PubMed:30046111

Appears in Networks:
Annotations
Cell Ontology (CL)
neuron
Confidence
Medium
MeSH
Hippocampus

p(MGI:Vegfc) increases bp(GO:cognition) View Subject | View Object

The beneficial effect of mVEGF-C treatment in mice from the sham group, which performed significantly better in the NLR (Fig. 2n, o) and MWM (Fig. 2p–r) tests, was abrogated in mice in which the CSF-draining lymphatic vessels had been ligated PubMed:30046111

Appears in Networks:
Annotations
Confidence
High

p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) View Subject | View Object

Accordingly, the drainage of CSF macromolecules into dCLNs was significantly higher in sham-operated mice treated with mVEGF-C compared to all other groups (Fig. 2s, t) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Neck

p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) View Subject | View Object

Independently of the model, the level of CSF tracer drained into the dCLNs was comparable between transgenic mice with Alzheimer’s disease and age-matched wild-type littermates (Extended Data Fig. 8p–s) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebrospinal Fluid
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(MGI:Vegfc) causesNoChange a(CHEBI:"amyloid-beta") View Subject | View Object

Moreover, viral expression of mVEGF-C did not significantly affect the diameter of meningeal lymphatic vessels, the level of amyloid-β in the CSF, or amyloid-β deposition in the hippocampus (Extended Data Fig. 8g–n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebrospinal Fluid
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") View Subject | View Object

Similarly, the morphology and coverage of meningeal lymphatic vessels did not differ between wild-type and 5xFAD mice at 3–4 months of age (Extended Data Fig. 8t, u) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.