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bp(GO:"cellular respiration")

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Entity

Name
cellular respiration
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
MeSH
Mitochondria
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") View Subject | View Object

Citrate synthase activity is a surrogate marker of total mitochondrial content/mass, and was similar across genotypes and brain regions (Figure 3i) suggesting that the defects in cellular respiration were due to altered mitochondrial quality, not content/mass PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

sec(a(CHEBI:adrenaline)) increases bp(GO:"cellular respiration") View Subject | View Object

The release of epinephrine stimulates the body and causes a sudden release of glucose as well as an increase in blood pressure, respiration, and heart rate PubMed:28391535

Appears in Networks:
Annotations
MeSH
Adrenal Glands

a(CHEBI:heme) decreases bp(GO:"cellular respiration") View Subject | View Object

This experiment demonstrated that under serum-free conditions, 4 hours of exposure to NaOH-dissolved heme induced complete deterioration of mitochondrial respiration at concentrations as low as 10 lmolL1, while exposure to albumin-associated heme in the presence of 2% FCS stimulated respiratory capacity to levels above baseline. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Mitochondria
Text Location
Results

a(MESH:ferrylhemoglobin) negativeCorrelation bp(GO:"cellular respiration") View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

complex(a(CHEBI:heme), p(HGNC:ALB)) positiveCorrelation bp(GO:"cellular respiration") View Subject | View Object

This experiment demonstrated that under serum-free conditions, 4 hours of exposure to NaOH-dissolved heme induced complete deterioration of mitochondrial respiration at concentrations as low as 10 lmolL1, while exposure to albumin-associated heme in the presence of 2% FCS stimulated respiratory capacity to levels above baseline. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Mitochondria
Text Location
Results

Out-Edges 3

bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) View Subject | View Object

Citrate synthase activity is a surrogate marker of total mitochondrial content/mass, and was similar across genotypes and brain regions (Figure 3i) suggesting that the defects in cellular respiration were due to altered mitochondrial quality, not content/mass PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

bp(GO:"cellular respiration") negativeCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

bp(GO:"cellular respiration") positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

This experiment demonstrated that under serum-free conditions, 4 hours of exposure to NaOH-dissolved heme induced complete deterioration of mitochondrial respiration at concentrations as low as 10 lmolL1, while exposure to albumin-associated heme in the presence of 2% FCS stimulated respiratory capacity to levels above baseline. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Mitochondria
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.