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bp(GO:"neuronal signal transduction")

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Entity

Name
neuronal signal transduction
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

In-Edges 3

act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus

a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") View Subject | View Object

It was also shown that soluble AβOs may directly trigger dysfunction of neural signaling, which leads to early memory loss and the progression of dementia in AD. PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High

p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

Appears in Networks:

Out-Edges 2

bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

Significant transcriptional alterations were also associated with excitatory synaptic remodelling and plasticity, hippocampal neuronal transmission, learning and memory and ageing-related cognitive decline (Extended Data Fig. 5q, r) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus

bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.