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a(CHEBI:"calcium cation")

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Entity

Name
calcium cation
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 2

bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) View Subject | View Object

whereas those on microglia increase intracellular calcium levels and signalling cascades without using channel function, and those on macrophages and other immunological cells signal through the JAK2/STAT3 tran- scription factor pathway PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

The binding of ACh or nicotine activates neuronal nAChRs thus leading to the influx of Na+ and Ca2+ and ef- flux of K+. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 3

a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") View Subject | View Object

The cytoplasmic in- crease in calcium triggers the secretion of mitogenic factors and activates the signalling cascades involved in cell prolif- eration, migration and angiogenesis and the inhibition of apoptosis PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") View Subject | View Object

The cytoplasmic in- crease in calcium triggers the secretion of mitogenic factors and activates the signalling cascades involved in cell prolif- eration, migration and angiogenesis and the inhibition of apoptosis PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) View Subject | View Object

The cytoplasmic in- crease in calcium triggers the secretion of mitogenic factors and activates the signalling cascades involved in cell prolif- eration, migration and angiogenesis and the inhibition of apoptosis PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.