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GABAergic Neurons

Name
GABAergic Neurons
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

In most cases, the exogenously applied ACh caused action potential firing by the GABA neuron that consequently regulated the activity of nearby pyramidal neurons (100, 103). PubMed:17009926

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) View Subject | View Object

In midbrain, chronic nicotine treatment elicits a general increase in alpha4beta2* nAChRs in GABAergic neurons, but only in axon terminals of DA neurons PubMed:21482353

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Mesencephalon

a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) View Subject | View Object

These contrasting effects on GABA and DA neurons are due to upregulated alpha4* nAChR responses in GABA neurons, at both somata and synaptic terminals PubMed:21482353

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release. PubMed:21787755

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release. PubMed:21787755

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.