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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

bp(MESH:"Cell Survival") positiveCorrelation p(HGNC:ALB) View Subject | View Object

As shown in Fig. 2d, heme/H2O2/ NO2−-induced loss of cell viability was significantly attenuated by BSA or BSA-T pretreatment, and BSA was more effective than BSA-T. PubMed:30324533

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Hematoma
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bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

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bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

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Hematoma
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Out-Edges 14

p(HGNC:ALB) causesNoChange bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683

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Erythrocyte Membrane
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Sepsis
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p(HGNC:ALB) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683

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Erythrocyte Membrane
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Sepsis
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p(HGNC:ALB) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

HRG and HSA both inhibited PS expression when their concentrations were increased to 10 and 100 mg/mL (Fig. 2B). PubMed:29544683

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Erythrocyte Membrane
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Sepsis
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p(HGNC:ALB) causesNoChange a(HM:"erythrocyte-endothelium adhesion") View Subject | View Object

HRG treatment significantly inhibited the attachment of erythrocytes to the vascular endothelial cell monolayer in a concentration dependent manner (Fig. 4A and B), while HSA did not affect the adhesion. PubMed:29544683

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Erythrocyte Membrane
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Sepsis
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p(HGNC:ALB) decreases a(CHEBI:heme) View Subject | View Object

Serum albumin (SA) can act as the heme scavenger by forming heme-SA complex [2, 4–8]. PubMed:30324533

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Introduction

p(HGNC:ALB) positiveCorrelation bp(MESH:"Cell Survival") View Subject | View Object

As shown in Fig. 2d, heme/H2O2/ NO2−-induced loss of cell viability was significantly attenuated by BSA or BSA-T pretreatment, and BSA was more effective than BSA-T. PubMed:30324533

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MeSH
Hematoma
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Results

p(HGNC:ALB) decreases act(complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite))) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

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MeSH
Hematoma
Text Location
Results

p(HGNC:ALB) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

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MeSH
Hematoma
Text Location
Results

p(HGNC:ALB) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

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Hematoma
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Results

p(HGNC:ALB) decreases bp(MESH:"Protein Carbonylation") View Subject | View Object

Both BSA and BSA-T attenuated heme/H2O2/NO2 −-induced protein carbonylation and lipid peroxidation. PubMed:30324533

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Hematoma
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p(HGNC:ALB) decreases bp(MESH:"Lipid Peroxidation") View Subject | View Object

Both BSA and BSA-T attenuated heme/H2O2/NO2 −-induced protein carbonylation and lipid peroxidation. PubMed:30324533

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Hematoma
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p(HGNC:ALB) decreases a(CHEBI:"3-nitrotyrosine") View Subject | View Object

Of note, incubation with BSA or BSA-T for 24 h decreased heme/ H2O2/NO2 −-derived 3-NT deposits as compared with heme/ H2O2/NO2 − treatment alone, and BSA is more effective on suppressing the formation of 3-NT than BSA-T (Fig. 5b). PubMed:30324533

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Hematoma
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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.