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complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite))

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Components

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

a(CHEBI:"3-nitrotyrosine") positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

As shown in Fig. 5a, significant amount of 3-NT emerged in cultures following heme/H2O2/NO2 − treatment for 24 h (red staining), indicating the strongest nitrative stress level. PubMed:30324533

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Hematoma
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a(CHEBI:"carbonyl group") positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

The carbonyl contents (Fig. 4a) and MDA level (Fig. 4c) from heme/H2O2/NO2 −-treated cells were the highest under all conditions. PubMed:30324533

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Hematoma
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a(CHEBI:malonaldehyde) positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

The carbonyl contents (Fig. 4a) and MDA level (Fig. 4c) from heme/H2O2/NO2 −-treated cells were the highest under all conditions. PubMed:30324533

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Hematoma
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bp(MESH:"Cell Survival") negativeCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

As illustrated in Fig. 2d, the loss of viability by heme/H2O2 and heme/H2O2/NO2 − was approximately 53 ± 3.8% and 65 ± 4.5%, respectively, which further confirmed that NO2 − dramatically enhances heme/ H2O2 toxicity.This result is well consistent with previous reports [3, 13]. PubMed:30324533

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MeSH
Hematoma
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bp(MESH:Apoptosis) positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

Figure 3a depicts the morphology of SHSY5Y cells after treated with various conditions. Compared with heme/H2O2 treatment, cells exposing to heme/ H2O2/NO2 − exacerbated cell apoptotic and reduced cell yield. PubMed:30324533

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Hematoma
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bp(MESH:Apoptosis) positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

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MeSH
Hematoma
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Results

p(HGNC:ALB) decreases act(complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite))) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

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MeSH
Hematoma
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p(HGNC:ALB, pmod(Ph, Tyr)) decreases act(complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite))) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

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MeSH
Hematoma
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Results

Out-Edges 9

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) hasComponent a(CHEBI:"hydrogen peroxide") View Subject | View Object

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complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) hasComponent a(CHEBI:heme) View Subject | View Object

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complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) hasComponent a(CHEBI:nitrite) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) negativeCorrelation bp(MESH:"Cell Survival") View Subject | View Object

As illustrated in Fig. 2d, the loss of viability by heme/H2O2 and heme/H2O2/NO2 − was approximately 53 ± 3.8% and 65 ± 4.5%, respectively, which further confirmed that NO2 − dramatically enhances heme/ H2O2 toxicity.This result is well consistent with previous reports [3, 13]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

Figure 3a depicts the morphology of SHSY5Y cells after treated with various conditions. Compared with heme/H2O2 treatment, cells exposing to heme/ H2O2/NO2 − exacerbated cell apoptotic and reduced cell yield. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation a(CHEBI:"carbonyl group") View Subject | View Object

The carbonyl contents (Fig. 4a) and MDA level (Fig. 4c) from heme/H2O2/NO2 −-treated cells were the highest under all conditions. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation a(CHEBI:malonaldehyde) View Subject | View Object

The carbonyl contents (Fig. 4a) and MDA level (Fig. 4c) from heme/H2O2/NO2 −-treated cells were the highest under all conditions. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation a(CHEBI:"3-nitrotyrosine") View Subject | View Object

As shown in Fig. 5a, significant amount of 3-NT emerged in cultures following heme/H2O2/NO2 − treatment for 24 h (red staining), indicating the strongest nitrative stress level. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.