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a(MESH:Erythrocytes)

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Entity

Name
Erythrocytes
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) View Subject | View Object

Dietary pre-administration of docosahexaenoic acid prevents RBCs from oxidative damage due to its antioxidative characteristic and also increases Aβ degradation by RBC in a lipid raft-dependent manner (Hashimoto et al. 2015) PubMed:29626319

Appears in Networks:

complex(a(MESH:Erythrocytes), p(HGNC:CR1)) hasComponent a(MESH:Erythrocytes) View Subject | View Object

Appears in Networks:

a(CHEBI:heme) positiveCorrelation deg(a(MESH:Erythrocytes)) View Subject | View Object

Upon degradation of RBCs in the erythrophagosome, heme is imported into the cytoplasm for degradation by the heme-degrading enzyme heme oxygenase-1 (HMOX1) [7]. PubMed:30248094

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Text Location
Introduction

bp(MESH:Hemostasis) association a(MESH:Erythrocytes) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

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Text Location
Review

path(MESH:Thrombosis) association a(MESH:Erythrocytes) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

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Text Location
Review

Out-Edges 11

a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) View Subject | View Object

Accordingly, ACh and its synthesizing enzyme choline acetyltransferase (ChAT), are found in human and animal erythrocytes, immune cells, endothelial and epithelial cells (including airway epithelial cells) and placenta cells. Small amounts of ACh are even found in blood PubMed:28901280

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a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") View Subject | View Object

Accordingly, ACh and its synthesizing enzyme choline acetyltransferase (ChAT), are found in human and animal erythrocytes, immune cells, endothelial and epithelial cells (including airway epithelial cells) and placenta cells. Small amounts of ACh are even found in blood PubMed:28901280

Appears in Networks:

a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Aβ in periphery is mainly cleared by blood components, such as red cells (RBCs) and monocytes, or some tissues and organs, such as the liver and kidney (Fig. 2) PubMed:29626319

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a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Dietary pre-administration of docosahexaenoic acid prevents RBCs from oxidative damage due to its antioxidative characteristic and also increases Aβ degradation by RBC in a lipid raft-dependent manner (Hashimoto et al. 2015) PubMed:29626319

Appears in Networks:

a(MESH:Erythrocytes) association path(MESH:Thrombosis) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Erythrocytes) association bp(MESH:Hemostasis) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Erythrocytes) increases a(HM:"Platelet margination") View Subject | View Object

A remarkable rheological effect of RBCs that affects platelets in hemostasis and thrombosis is that RBCs preferentially move down the center of blood vessel, causing margination of platelets, so that they are poised to adhere preferentially to the site of vessel-wall injury [10]. PubMed:28458720

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a(MESH:Erythrocytes) increases bp(MESH:"Platelet Adhesiveness") View Subject | View Object

A remarkable rheological effect of RBCs that affects platelets in hemostasis and thrombosis is that RBCs preferentially move down the center of blood vessel, causing margination of platelets, so that they are poised to adhere preferentially to the site of vessel-wall injury [10]. PubMed:28458720

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Review

a(MESH:Erythrocytes) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

RBCs can modulate platelet reactivity directly through either chemical signaling or adhesive RBC-platelet interactions. RBCs promote platelet aggregation and degranulation by releasing ATP and ADP under low pO2, low pH and in response to mechanical deformation [27, 28]. PubMed:28458720

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Annotations
MeSH
Veins
Text Location
Review

a(MESH:Erythrocytes) increases bp(MESH:"Cell Degranulation") View Subject | View Object

RBCs can modulate platelet reactivity directly through either chemical signaling or adhesive RBC-platelet interactions. RBCs promote platelet aggregation and degranulation by releasing ATP and ADP under low pO2, low pH and in response to mechanical deformation [27, 28]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

deg(a(MESH:Erythrocytes)) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Upon degradation of RBCs in the erythrophagosome, heme is imported into the cytoplasm for degradation by the heme-degrading enzyme heme oxygenase-1 (HMOX1) [7]. PubMed:30248094

Appears in Networks:
Annotations
Text Location
Introduction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.