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bp(MESH:Hemostasis)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Hemostasis
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(MESH:"Cell-Derived Microparticles") positiveCorrelation bp(MESH:Hemostasis) View Subject | View Object

The ability of cells to generate MPs in vivo is an important regulatory mechanism of physiologic reactions, a means for intercellular communications and a pathogenic component in many diseases that impact hemostasis and thrombosis [50, 51]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(MESH:"NADPH Oxidase") increases bp(MESH:Hemostasis) View Subject | View Object

Inhibiting NADPH oxidase, its upstream activator protein kinase C or antioxidants inhibit haem-mediated stasis, Weibel-Palade body degranulation and oxidant production by the endothelium (Belcher et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Erythrocytes) association bp(MESH:Hemostasis) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Erythrocyte Volume") positiveCorrelation bp(MESH:Hemostasis) View Subject | View Object

Thus the volume fraction of red cells may have a significant impact on hemostasis and thrombosis, with the nature of the effect related to the flow conditions [9]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

complex(a(CHEBI:lipopolysaccharide), p(HGNC:TLR4)) increases bp(MESH:Hemostasis) View Subject | View Object

Lipopolysaccharide (LPS)—the main constituent of the outer cell wall of Gram-negative bacteria—is known to bind to the pathogen recognition receptor TLR-4 and to activate the innate immune and hemostatic systems. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation bp(MESH:Hemostasis) View Subject | View Object

Thus, haemolysis results in NO scavenging, systemic vasoconstriction and increased blood stasis, thereby affecting one of the principle components of Virchow’s Triad. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation bp(MESH:Hemostasis) View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 5

bp(MESH:Hemostasis) positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:Hemostasis) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Thus, haemolysis results in NO scavenging, systemic vasoconstriction and increased blood stasis, thereby affecting one of the principle components of Virchow’s Triad. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(MESH:Hemostasis) association a(MESH:Erythrocytes) View Subject | View Object

However, in the past few decades there has been increasing evidence that RBCs have a variety of active functions in hemostasis and thrombosis that are significant and need to be taken into account in assessing health and disease. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:Hemostasis) positiveCorrelation bp(MESH:"Erythrocyte Volume") View Subject | View Object

Thus the volume fraction of red cells may have a significant impact on hemostasis and thrombosis, with the nature of the effect related to the flow conditions [9]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:Hemostasis) positiveCorrelation a(MESH:"Cell-Derived Microparticles") View Subject | View Object

The ability of cells to generate MPs in vivo is an important regulatory mechanism of physiologic reactions, a means for intercellular communications and a pathogenic component in many diseases that impact hemostasis and thrombosis [50, 51]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.