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bp(MESH:"Platelet Aggregation")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Platelet Aggregation
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

a(CHEBI:"3',5'-cyclic GMP") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

NO inhibits platelet aggregation mediated by guanylate cyclase activation with a subsequent rise in cGMP (Faint et al, 1991). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"L-arginine") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

Platelet deposition and adhesion at sites of subintimal injury are increased by free haemoglobin or inhibition of NO production; this effect can be prevented by infusions of L-arginine, the precursor of NO (Olsen et al, 1996). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"nitric oxide") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

Platelet deposition and adhesion at sites of subintimal injury are increased by free haemoglobin or inhibition of NO production; this effect can be prevented by infusions of L-arginine, the precursor of NO (Olsen et al, 1996). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"nitric oxide") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

Both processes decrease the availability of NO, which normally maintains smooth muscle cell relaxation, inhibits platelet activation and aggregation, and has anti-inflammatory effects on the endothelium. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

a(CHEBI:heme) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

Platelet deposition and adhesion at sites of subintimal injury are increased by free haemoglobin or inhibition of NO production; this effect can be prevented by infusions of L-arginine, the precursor of NO (Olsen et al, 1996). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:heme) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

Moreover, in vitro studies have demonstrated that heme binds to human platelets and induces platelet activation and aggregation [37–39]. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(MESH:Erythrocytes) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

RBCs can modulate platelet reactivity directly through either chemical signaling or adhesive RBC-platelet interactions. RBCs promote platelet aggregation and degranulation by releasing ATP and ADP under low pO2, low pH and in response to mechanical deformation [27, 28]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

p(HGNC:HBB) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

When RBCs are damaged by high shear in continuous flow ventricular assist devices, free hemoglobin induces platelet aggregation, contributing to high risk of thrombotic complications [33]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Acute Coronary Syndrome
Text Location
Review

p(HGNC:HBB) increases bp(MESH:"Platelet Aggregation") View Subject | View Object

Extracellular hemoglobin sequesters NO and thus promotes activation of endothelial cells and adhesion/aggregation of platelets [64]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

p(HGNC:SELP) positiveCorrelation bp(MESH:"Platelet Aggregation") View Subject | View Object

In patients with SCD (Wun et al, 1998) and b-thalassaemia (Ruf et al, 1997), flow cytometry demonstrates the presence of an increased fraction of platelets expressing P-selectin, a platelet membrane receptor that mediates platelet–endothelial interactions. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation bp(MESH:"Platelet Aggregation") View Subject | View Object

In addition, reduced NO bioavailability induces platelet activation and aggregation, leading to thrombosis in a mouse model of intravascular haemolysis (Hu et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 3

bp(MESH:"Platelet Aggregation") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

In addition, reduced NO bioavailability induces platelet activation and aggregation, leading to thrombosis in a mouse model of intravascular haemolysis (Hu et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(MESH:"Platelet Aggregation") increases path(MESH:Thrombosis) View Subject | View Object

When RBCs are damaged by high shear in continuous flow ventricular assist devices, free hemoglobin induces platelet aggregation, contributing to high risk of thrombotic complications [33]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Acute Coronary Syndrome
Text Location
Review

bp(MESH:"Platelet Aggregation") positiveCorrelation p(HGNC:SELP) View Subject | View Object

In patients with SCD (Wun et al, 1998) and b-thalassaemia (Ruf et al, 1997), flow cytometry demonstrates the presence of an increased fraction of platelets expressing P-selectin, a platelet membrane receptor that mediates platelet–endothelial interactions. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.