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complex(a(MESH:"Blood Transfusion"), p(MGI:Hp))

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 12

a(CHEBI:"iron(2+)") negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Only transfusion of SRBCs and haptoglobin prevented SRBC-induced renal iron accumulation (Figure 6A and B). PubMed:27515135

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MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

In comparison to mice transfused with SRBCs alone, the spleens of mice resuscitated with SRBCs and haptoglobin contained more iron (Figure 6D). PubMed:27515135

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MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

a(MESH:Mortality) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

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MeSH
Hemorrhage
Text Location
Results

p(HGNC:HBB) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Co-administration of haptoglobin with SRBCs results in a prolonged increase in plasma hemoglobin levels for more than 48 hours after transfusion. PubMed:27515135

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MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

p(MGI:Havcr1) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hmox1) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Resuscitation with SRBCs and haptoglobin prevented the increase in SRBC-induced renal HO-1 expression (Figure 7F). PubMed:27515135

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MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Il6) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Lcn2) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

p(MGI:Mki67) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

The number of Ki-67 positive cells in kidneys from mice that received SRBCs and haptoglobin was similar to the number of Ki-67 positive cells in kidneys from mice that received FRBCs.. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemoglobinuria) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemoglobinuria) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

r(MGI:Lcn2) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

Out-Edges 14

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) hasComponent a(MESH:"Blood Transfusion") View Subject | View Object

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complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) hasComponent p(MGI:Hp) View Subject | View Object

Appears in Networks:

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation a(MESH:Mortality) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) positiveCorrelation p(HGNC:HBB) View Subject | View Object

Co-administration of haptoglobin with SRBCs results in a prolonged increase in plasma hemoglobin levels for more than 48 hours after transfusion. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Havcr1) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation r(MGI:Lcn2) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Lcn2) View Subject | View Object

However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Mki67) View Subject | View Object

The number of Ki-67 positive cells in kidneys from mice that received SRBCs and haptoglobin was similar to the number of Ki-67 positive cells in kidneys from mice that received FRBCs.. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Only transfusion of SRBCs and haptoglobin prevented SRBC-induced renal iron accumulation (Figure 6A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

In comparison to mice transfused with SRBCs alone, the spleens of mice resuscitated with SRBCs and haptoglobin contained more iron (Figure 6D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Hmox1) View Subject | View Object

Resuscitation with SRBCs and haptoglobin prevented the increase in SRBC-induced renal HO-1 expression (Figure 7F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Il6) View Subject | View Object

Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.