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a(HBP:"alpha-6-containing nAChR")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
alpha-6-containing nAChR
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

In-Edges 7

a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

This makes the hypothesis particularly intriguing that a6*-nAChRs play roles in nicotine dependence. PubMed:21787755

Appears in Networks:

path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

Out-Edges 6

a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) View Subject | View Object

a6 subunits are not widely expressed in the brain, but they are prevalent in midbrain dopaminergic (DAergic) regions associated with pleasure, reward, and mood control PubMed:21787755

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Recently, we reported a novel discovery that functional a6*-nAChRs are located on GABAergic presynaptic boutons associated with VTA DAergic neurons, where these a6*- nAChRs mediate nicotinic modulation of GABA release onto those DAergic neurons [122]. PubMed:21787755

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

This makes the hypothesis particularly intriguing that a6*-nAChRs play roles in nicotine dependence. PubMed:21787755

Appears in Networks:

a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") View Subject | View Object

There is good evidence that a6*-nAChRs, in particular, modulate neurotransmitter release in multiple brain regions. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.