1. Catalog
  2. Nodes
  3. path(MESH:"Tobacco Use Disorder")

path(MESH:"Tobacco Use Disorder")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Tobacco Use Disorder
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 5

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 18

act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

It has long been known that smokers tend to be leaner, and yet approximately four times more likely to become insulin resistant and develop type I diabetes (497), a condition that is more commonly observed in obese patients. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

However, epidemiological studies have reported that heavy smokers are less likely to experience PD (see reviews in Refs. 384, 385). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Indeed, presynaptic effects of nAChRs in regulating dopamine release in basal ganglia and prefrontal cortex likely participate in nicotine’s addictive and cognitive effects, respectively (Jasinska et al., 2014) PubMed:28445721

Appears in Networks:

act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Developmental changes in nAChR functions may play a role in nicotine addiction, as a central question in tobacco control is young adult smokers’ marked sensitivity to developing nicotine dependence (DSM-V Nicotine Workgroup, 2010; DiFranza et al., 2000; Difranza, 2010) PubMed:21482353

Appears in Networks:

p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

Mutations in nicotinic receptor subunits are linked to human disease, alpha4 and beta2 in some epilepsies, alpha7 in schizophrenia, and alpha5 in nicotine addiction; and each mutation ultimately manifests itself as an imbalance in the properties of neuronal circuits PubMed:21482353

Appears in Networks:

p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") View Subject | View Object

Third, persons with schizophrenia have the greatest rate and intensity of cigarette smoking of any identifiable subgroup in the population PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

b4 subunit mRNA colocalizes with a4 subunit mRNA in many brain regions [37,38] that could be involved in complex behaviors including nicotine dependence. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") View Subject | View Object

This makes the hypothesis particularly intriguing that a6*-nAChRs play roles in nicotine dependence. PubMed:21787755

Appears in Networks:

a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

Appears in Networks:

g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Human genetic studies have shown that the non- synonymous coding SNP D398N is associated with lung cancer and nicotine dependence PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 24

path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") View Subject | View Object

There is current evidence that nAChRs present in skin cells modulate the responses triggered by inflammatory stimuli applied to the skin (354). Smoking is a welldefined risk factor in delayed wound healing and possibly the development of premature facial wrinkling (226). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Skin
Text Location
Review

path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") View Subject | View Object

There is current evidence that nAChRs present in skin cells modulate the responses triggered by inflammatory stimuli applied to the skin (354). Smoking is a welldefined risk factor in delayed wound healing and possibly the development of premature facial wrinkling (226). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Skin
Text Location
Review

path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) View Subject | View Object

In fact, the relationship between tobacco abuse (including smokeless) and difficulty in healing, increased susceptibility to infection (especially oral), enhanced expression of indicators of skin aging, and increased cancer risk are all well-documented (383, 452). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") View Subject | View Object

Modulation by nicotine of inflammatory responses in the intestines is much better reported. Early studies found that patients with ulcerative colitis who stopped smoking tobacco developed the disease or exhibited more severe disease progression, which was ameliorated by either returning to smoking (58, 401, 466), or, in some cases, administering nicotine through transdermal patches (313).In contrast, patients with Crohn’s disease experience much more severe disease when smoking (401). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Intestines
Text Location
Review

path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") View Subject | View Object

Modulation by nicotine of inflammatory responses in the intestines is much better reported. Early studies found that patients with ulcerative colitis who stopped smoking tobacco developed the disease or exhibited more severe disease progression, which was ameliorated by either returning to smoking (58, 401, 466), or, in some cases, administering nicotine through transdermal patches (313).In contrast, patients with Crohn’s disease experience much more severe disease when smoking (401). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Intestines
Text Location
Review

path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") View Subject | View Object

It has long been known that smokers tend to be leaner, and yet approximately four times more likely to become insulin resistant and develop type I diabetes (497), a condition that is more commonly observed in obese patients. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

However, epidemiological studies have reported that heavy smokers are less likely to experience PD (see reviews in Refs. 384, 385). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) View Subject | View Object

Indeed, presynaptic effects of nAChRs in regulating dopamine release in basal ganglia and prefrontal cortex likely participate in nicotine’s addictive and cognitive effects, respectively (Jasinska et al., 2014) PubMed:28445721

Appears in Networks:

path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) View Subject | View Object

Mutations in nicotinic receptor subunits are linked to human disease, alpha4 and beta2 in some epilepsies, alpha7 in schizophrenia, and alpha5 in nicotine addiction; and each mutation ultimately manifests itself as an imbalance in the properties of neuronal circuits PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) View Subject | View Object

Developmental changes in nAChR functions may play a role in nicotine addiction, as a central question in tobacco control is young adult smokers’ marked sensitivity to developing nicotine dependence (DSM-V Nicotine Workgroup, 2010; DiFranza et al., 2000; Difranza, 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) View Subject | View Object

Third, persons with schizophrenia have the greatest rate and intensity of cigarette smoking of any identifiable subgroup in the population PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) View Subject | View Object

Because alpha4beta2 nAChRs are the most susceptible to nicotine-induced upregulation, the data again seem consistent with the idea that selective upregulation of alpha4beta2 nAChRs underlies nicotine dependence PubMed:21482353

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) View Subject | View Object

a4b2-nAChRs have been implicated in nicotine self-administration, reward, and depen- dence, and in diseases such as Alzheimer’s and epilepsy [1–5,27–33]. PubMed:21787755

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") View Subject | View Object

b4 subunit mRNA colocalizes with a4 subunit mRNA in many brain regions [37,38] that could be involved in complex behaviors including nicotine dependence. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") View Subject | View Object

This makes the hypothesis particularly intriguing that a6*-nAChRs play roles in nicotine dependence. PubMed:21787755

Appears in Networks:

path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) View Subject | View Object

Human genetic studies have shown that the non- synonymous coding SNP D398N is associated with lung cancer and nicotine dependence PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.