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bp(GO:"neurotransmitter secretion")

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Entity

Name
neurotransmitter secretion
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

In-Edges 7

p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

In some cases, the highly calcium-permeable α7-containing (α7∗) nAChRs mediate the increased release of neurotransmitter, but in other cases different nAChR subtypes are involved. PubMed:17009926

Appears in Networks:

p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

Presynaptic and preterminal nicotinic receptors enhance neurotransmitter release, and postsynaptic and nonsynaptic nAChRs mediate excitation as well as activity-dependent modulation of circuits and intracellular enzymatic processes. PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

Activation of presynaptic nAChRs increases the release of many different neurotransmitters (1, 2, 4, 5, 40, 41, 77–83). PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

Presynaptic and preterminal nAChRs increase the release of neurotransmitters in the hippocampus, particularly the main neurotransmitters, GABA and glutamate (41, 78, 81, 97). PubMed:17009926

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Presynaptic Terminals

p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

α7 AChRs can act at the presynaptic, postsynaptic or perisynaptic levels to facilitate the liberation of neurotransmitters, mediate synaptic transmission, or modulate the connections of different neurons by activating diverse second messenger routes [1,19,23–31]. PubMed:22040696

Appears in Networks:

a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") View Subject | View Object

There is good evidence that a6*-nAChRs, in particular, modulate neurotransmitter release in multiple brain regions. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") View Subject | View Object

For example, Bgt-sensitive a7-nAChRs have been implicated in processes such as vicinal control of neurotransmitter release [7,14], development and maintenance of neurites and synapses [18–20], long-term potentiation [95,96], seizures [97], and neuronal viability/death [21–24]. These intriguing findings underscore the need for further characterization of functional a7-nAChRs. PubMed:21787755

Appears in Networks:

Out-Edges 2

bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) View Subject | View Object

At the cellular level, nAChRs can underlie synaptic responses, neuronal excitability, and neurotransmitter release (Dajas-Bailador and Wonnacott, 2004; Gotti and Clementi, 2004; Hogg et al., 2003) PubMed:28445721

Appears in Networks:

bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") View Subject | View Object

For example, Bgt-sensitive a7-nAChRs have been implicated in processes such as vicinal control of neurotransmitter release [7,14], development and maintenance of neurites and synapses [18–20], long-term potentiation [95,96], seizures [97], and neuronal viability/death [21–24]. These intriguing findings underscore the need for further characterization of functional a7-nAChRs. PubMed:21787755

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.