1. Catalog
  2. Networks
  3. Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

Naturally-expressed nicotinic acetylcholine receptor subtypes 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:20:54.699243
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
42
Number Edges
67
Number Components
3
Network Density
0.0389082462253194
Average Degree
1.5952380952381
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
albuquerque2009 v1.0.0 43%
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype v1.0.0 38%
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0 29%
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0 29%
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1 24%
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1 24%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 23%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 21%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 21%
Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0 21%

Sample Edges

a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) View Subject | View Object

In terms of functional effects, nicotine acts acutely much in the way that ACh does, causing opening of nAChR channels. PubMed:21787755

sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) View Subject | View Object

There is an emerging consensus that nAChR a6 subunit mRNA and proteins are distributed in brain regions thought to be involved in reward and drug reinforcement, in theory being involved in DA release [135]. PubMed:21787755

Annotations
MeSH
Brain

sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) View Subject | View Object

There is an emerging consensus that nAChR a6 subunit mRNA and proteins are distributed in brain regions thought to be involved in reward and drug reinforcement, in theory being involved in DA release [135]. PubMed:21787755

Annotations
MeSH
Brain

a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) View Subject | View Object

In terms of functional effects, nicotine acts acutely much in the way that ACh does, causing opening of nAChR channels. PubMed:21787755

a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release. PubMed:21787755

Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:"excitatory chemical synaptic transmission")

In-Edges: 2 | Out-Edges: 1 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

bp(GO:"long-term synaptic potentiation")

In-Edges: 39 | Out-Edges: 20 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.