1. Catalog
  2. Namespaces
  3. MeSH
  4. Presynaptic Terminals

Presynaptic Terminals

Name
Presynaptic Terminals
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) View Subject | View Object

Simultaneously, nicotine activates presynaptic α7∗ nAChRs, boosting glutamatergic synaptic transmission onto DA neurons (23, 88, 123, 134). PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) View Subject | View Object

This effect of preterminal nAChRs is inhibited by tetrodotoxin, which blocks sodium channels and, thus, prevents the regenerative voltage-dependent activation of calcium channels in the presynaptic bouton. PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) View Subject | View Object

In addition, nAChR activity produces a depolarization that activates voltage-gated calcium channels in the presynaptic terminal (87). PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Presynaptic Terminals

p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

Presynaptic and preterminal nicotinic receptors enhance neurotransmitter release, and postsynaptic and nonsynaptic nAChRs mediate excitation as well as activity-dependent modulation of circuits and intracellular enzymatic processes. PubMed:17009926

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

Showing 5 of 20 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.