Presynaptic Terminals
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Sample Annotated Edges 5

a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) View Subject | View Object

Simultaneously, nicotine activates presynaptic α7∗ nAChRs, boosting glutamatergic synaptic transmission onto DA neurons (23, 88, 123, 134). PubMed:17009926

a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) View Subject | View Object

This effect of preterminal nAChRs is inhibited by tetrodotoxin, which blocks sodium channels and, thus, prevents the regenerative voltage-dependent activation of calcium channels in the presynaptic bouton. PubMed:17009926

bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) View Subject | View Object

In addition, nAChR activity produces a depolarization that activates voltage-gated calcium channels in the presynaptic terminal (87). PubMed:17009926

act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) View Subject | View Object

Postsynaptic β2∗ nAChRs initially depolarize DA neurons, causing them to fire action potentials while presynaptic α7∗ nAChRs boost glutamate release. PubMed:17009926

p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") View Subject | View Object

Presynaptic and preterminal nicotinic receptors enhance neurotransmitter release, and postsynaptic and nonsynaptic nAChRs mediate excitation as well as activity-dependent modulation of circuits and intracellular enzymatic processes. PubMed:17009926


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