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a(MESH:"NADPH Oxidase")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NADPH Oxidase
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

a(MESH:"Protein Kinase C") increases act(a(MESH:"NADPH Oxidase")) View Subject | View Object

Inhibiting NADPH oxidase, its upstream activator protein kinase C or antioxidants inhibit haem-mediated stasis, Weibel-Palade body degranulation and oxidant production by the endothelium (Belcher et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(MGI:Slc40a1) positiveCorrelation act(a(MESH:"NADPH Oxidase")) View Subject | View Object

Our study provides evidence that the increase in cellular oxidant levels, as a result of NADPH oxidase activity, was responsible for ferroportin induction by heme. PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

Out-Edges 3

a(MESH:"NADPH Oxidase") increases bp(MESH:Hemostasis) View Subject | View Object

Inhibiting NADPH oxidase, its upstream activator protein kinase C or antioxidants inhibit haem-mediated stasis, Weibel-Palade body degranulation and oxidant production by the endothelium (Belcher et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"NADPH Oxidase") increases a(HM:"Weibel Palade body degranulation") View Subject | View Object

Inhibiting NADPH oxidase, its upstream activator protein kinase C or antioxidants inhibit haem-mediated stasis, Weibel-Palade body degranulation and oxidant production by the endothelium (Belcher et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

act(a(MESH:"NADPH Oxidase")) positiveCorrelation p(MGI:Slc40a1) View Subject | View Object

Our study provides evidence that the increase in cellular oxidant levels, as a result of NADPH oxidase activity, was responsible for ferroportin induction by heme. PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.