1. Catalog
  2. Nodes
  3. bp(GO:"cytoskeleton organization")

bp(GO:"cytoskeleton organization")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
cytoskeleton organization
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 10

p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") View Subject | View Object

PP2A is an important player in many cellular functions. It controls cell metabolism by regulating the activity of the enzymes involved in glycolysis, lipid metabolism and catecholamine synthesis [8]. It also regulates various biological processes such as the cell cycle (by mediating cdc2 kinase activation), DNA replication, transcription and translation, signal transduction, cell proliferation, cytoskeleton dynamics and cell mobility and apoptosis. It has also been shown to play a role in cell transformation and cancer [9-12]. PubMed:23454242

Appears in Networks:

p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") View Subject | View Object

During meiosis I, Shugoshins binds to PP2A and dephosphorylates cohesion, which prevents spindle microtubules disassembly [37]. PP2APR55 also dephosphorylates vimentin (intermediate filament) and protects cytoskeleton disassembly [38]. PubMed:23454242

Appears in Networks:

bp(GO:"microtubule polymerization") increases bp(GO:"cytoskeleton organization") View Subject | View Object

Cytoskeleton organization and dynamics depend on the fine control of microtubule assembly, which relies on the interaction of microtubules with a specific class of proteins known as microtubule-associated protein (MAP). PubMed:30061532

Appears in Networks:

complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association bp(GO:"cytoskeleton organization") View Subject | View Object

Remarkably, the marked reduction of p35 levels in schizophrenic brains, which mirrors enhanced CDK5 activity [247], suggests a role for CDK5-CRMP2-dependent alterations of cytoskeleton architecture and psychiatric behavior PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") View Subject | View Object

Alterations in MAP2 immunoreactivity within the subiculum, entorhinal cortex, hippocampus, and prefrontal cortex have been suggested as the primary array of cytoskeletal abnormalities, which in turn result in impaired neurotransmission observed in schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Entorhinal Cortex
MeSH
Hippocampus
MeSH
Prefrontal Cortex

path(MESH:Schizophrenia) negativeCorrelation bp(GO:"cytoskeleton organization") View Subject | View Object

In addition, cytoskeletal derangement appears as a prominent feature of the ultrastructural pathology of schizophrenia PubMed:30061532

Appears in Networks:

Out-Edges 7

bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) View Subject | View Object

In mammals, B55 is associated with cytoskeletal dynamics and nuclear translocation. PubMed:23454242

Appears in Networks:

bp(GO:"cytoskeleton organization") negativeCorrelation path(MESH:Schizophrenia) View Subject | View Object

In addition, cytoskeletal derangement appears as a prominent feature of the ultrastructural pathology of schizophrenia PubMed:30061532

Appears in Networks:

bp(GO:"cytoskeleton organization") increases bp(GO:"neuron-neuron synaptic transmission") View Subject | View Object

Alterations in MAP2 immunoreactivity within the subiculum, entorhinal cortex, hippocampus, and prefrontal cortex have been suggested as the primary array of cytoskeletal abnormalities, which in turn result in impaired neurotransmission observed in schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Entorhinal Cortex
MeSH
Hippocampus
MeSH
Prefrontal Cortex

bp(GO:"cytoskeleton organization") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) View Subject | View Object

Remarkably, the marked reduction of p35 levels in schizophrenic brains, which mirrors enhanced CDK5 activity [247], suggests a role for CDK5-CRMP2-dependent alterations of cytoskeleton architecture and psychiatric behavior PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.