Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 2

In-Edges 6

a(MESH:Cytosol) association p(HGNC:PPP2R2A) View Subject | View Object

In neurons, B55 α and B55 β are localized in the cytoplasm, whereas B55 γ is localized in the cytoskeletal fraction. PubMed:23454242

a(MESH:Brain) association p(HGNC:PPP2R2A) View Subject | View Object

Within the brain, ACB55 (B55) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) View Subject | View Object

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660

Out-Edges 5

p(HGNC:PPP2R2A) association a(MESH:Cytosol) View Subject | View Object

In neurons, B55 α and B55 β are localized in the cytoplasm, whereas B55 γ is localized in the cytoskeletal fraction. PubMed:23454242

p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) View Subject | View Object

It has been shown in yeast that CDC55 (B55 in human) is essential for cytokinesis. PubMed:23454242

p(HGNC:PPP2R2A) association a(MESH:Brain) View Subject | View Object

Within the brain, ACB55 (B55) is the major PP2A B iso- form and it binds to tau with high affinity both in in vitro protein-protein interaction paradigms and in cell cultures [36, 37]. PubMed:22299660

p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.