Upload at 2018-04-03 15:16:34
Causal Biological Networks Database
The Hox network describes the causal mechanisms in the Hox signaling pathway that leads to cell proliferation as well as downstream targets of the HOX family members such as CDKN1A, CDKN1B, CDKN1C, ITGAV, and ITGB3.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 67%
Growth Factor-2.0-Rn v2.0 37%
Angiogenesis-2.0-Rn v2.0 33%
Cell Interaction-2.0-Rn v2.0 30%
Wound Healing-2.0-Rn v2.0 30%
Fibrosis-2.0-Rn v2.0 26%
Cell Cycle-2.0-Rn v2.0 22%
Hox-2.0-Hs v2.0 19%
Wound Healing-2.0-Hs v2.0 19%
ECM Degradation-2.0-Rn v2.0 19%

Sample Edges

p(RGD:Meox2) increases p(RGD:Cdkn1a)

"The homeodomain transcription factor MEOX2 is an important regulator of vascular cell proliferation and is a direct transcriptional activator of both p21(CIP1/WAF1) and p16(INK4a)" Other:22206000

p(RGD:Meox2) increases p(RGD:Cdkn1a)

p21 expression in HUVECs transduced with Gax was increased up to 5-fold as measured by Northern blot, and p21 promoter activity was activated by 4- to 5-fold. Other:12842453

Sample Nodes


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