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Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:43:48.488546
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
84
Number Edges
141
Number Components
1
Network Density
0.020223752151463
Average Degree
1.67857142857143
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 50%
PP2A and Alzheimer Disease v1.0.0 32%
Assembly and structure of protein phosphatase 2A v1.0.0 26%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 25%
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 24%
Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0 21%
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1 19%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 18%
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain v1.0.1 18%
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0 17%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) hasComponent a(CHEBI:"magnesium(2+)") View Subject | View Object

composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) hasComponent a(CHEBI:ATP) View Subject | View Object

p(HGNC:BCL2) hasVariant p(HGNC:BCL2, pmod(Ph)) View Subject | View Object

p(FPLX:AKT) hasVariant p(FPLX:AKT, pmod(Ph, Ser, 473)) View Subject | View Object

Sample Nodes

bp(GO:aging)

In-Edges: 27 | Out-Edges: 61 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))

In-Edges: 66 | Out-Edges: 47 | Explore Neighborhood | Download JSON

bp(GO:"apoptotic process")

In-Edges: 94 | Out-Edges: 13 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.