a(PUBCHEM:64627)

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64627

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PUBCHEM

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64627 increases neuronal activity (Fos mRNA) both in proaggregant Tau transgenic slices and controls, although in case of the proaggregant slices neuronal activity is almost doubled, yielding levels similar to those of treated littermate control slices (Fig. 4D) PubMed:27671637

64627 increases neuronal activity (Fos mRNA) both in proaggregant Tau transgenic slices and controls, although in case of the proaggregant slices neuronal activity is almost doubled, yielding levels similar to those of treated littermate control slices (Fig. 4D) PubMed:27671637

In line with these observations, the presynaptic impairment in proaggregant Tau transgenic slices can be reversed by 64627 or BSc3094 without causing adverse effects in controls (Fig. 4F and Fig. S6) PubMed:27671637

Indeed, the reduced level of spines seen in proaggregant Tau transgenic slices are normalized when treated with 64627, whereas no significant changes are found in antiaggregant Tau transgenic slices or littermate controls (Fig. 5 A and B) PubMed:27671637

The axonal density of mitochondria, which is slightly lower in proaggregant compared with antiaggregant Tau transgenic slices, is marginally decreased by 64627 treatment albeit in a genotype-independent manner (Fig. S7) PubMed:27671637