1. Catalog
  2. Namespaces
  3. Cell Ontology (CL)
  4. hippocampal neuron

hippocampal neuron

Name
hippocampal neuron
Namespace Keyword
Cell
Namespace
Cell Ontology (CL)
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno

Sample Annotated Edges 5

bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") View Subject | View Object

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons PubMed:16273023

Appears in Networks:
Annotations
MeSH
Mitochondria
Cell Ontology (CL)
hippocampal neuron
MeSH
Hippocampus

a(HBP:"Tau aggregates") association p(HGNC:SYK) View Subject | View Object

Most importantly, pathological tau species clearly colo- calize with pSyk (Y525/526) in hippocampal neurons (Fig. 4b). PubMed:28877763

Appears in Networks:
Annotations
Cell Ontology (CL)
hippocampal neuron

p(HGNC:MAPT, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates") View Subject | View Object

Hippocampal neurons of Tg Tau P301S mice exhibit a high level of tau hyperphosphorylation (Fig. 4b) as well as an accumulation of pathogenic tau conformers (MC1, not shown) compared to WT littermates (Fig. 4a). PubMed:28877763

Appears in Networks:
Annotations
Cell Ontology (CL)
hippocampal neuron

Showing 5 of 7 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.