a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047")

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PubMed:16273023

In healthy individuals, the glutamatergic neurotransmission cycle begins in the mitochondria of hippocampal neurons, where the enzyme glutaminase catalyzes the conversion of glutamine to glutamate. Next, the vesicular glutamate transporter molecule mediates the packaging of these glutamate molecules into vesicles. Glutamate-containing vesicles are then released from the neuron, resulting in elevated synaptic concentrations of free glutamate, which can transmit neural signals by interacting with glutamatergic receptors on postsynaptic neurons

Related Edges 2

• bp(GO:"GO:0014047") increases bp(GO:"GO:0035249")
• act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)")

MeSH

Mitochondria

Cell Ontology (CL)

hippocampal neuron

MeSH

Hippocampus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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