1. Catalog
  2. Nodes
  3. complex(GO:"NLRP1 inflammasome complex")

complex(GO:"NLRP1 inflammasome complex")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Entity

Name
NLRP1 inflammasome complex
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 13

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph

a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space
NeuroMMSigDB
Caspase subgraph

bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Thus, it is not surprising that effector and memory CD4+ T cells have the capacity to inhibit the activation of the NLRP1 and NLRP3 inflammasomes in a contact-dependent manner, possibly via TNFR superfamily molecules such as CD40 ligand (CD40L)70. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) hasComponent complex(GO:"NLRP1 inflammasome complex") View Subject | View Object

Appears in Networks:

a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Probenecid has also been demonstrated to reduce the activation of the NLRP1 inflammasome, and improve the learning performance in age-related cognitive decline (Mawhinney et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Aging, another risk factor of AD, has been found to activate the NLRP1 inflammasome and upregulate IL-18 and IL-1β levels in the hippocampus of aged mice (Mawhinney et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
NeuroMMSigDB
Interleukin signaling subgraph

complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

As for the NLRP1 and NLRP3 inflammasomes, the oligomerzied NLRs recruit and interact with the adaptor protein ASC, which in turn recruits the effector protein procaspase-1 that is central to the activation of inflammasomes (Huang et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

A subsequent study demonstrated that P2X7 purinergic receptor is involved in the activation of NLRP1 inflammasome (Silverman et al., 2009) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Similarly, the P2X7 purinergic receptor has been shown to activate the NLRP1 inflammasome in primary neurons (Silverman et al., 2009) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Given that P2X4 and P2X7 are the major purinergic P2X receptor subtypes, a study of spinal cord injury in P2X4 knock-out mice showed a significant reduction in inflammasome activation and proinflammatory cytokine production as compared to wild type (de Rivero Vaccari et al., 2012), supporting the involvement of purinergic receptor P2X4 in the activation of the NLRP1 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Given that P2X4 and P2X7 are the major purinergic P2X receptor subtypes, a study of spinal cord injury in P2X4 knock-out mice showed a significant reduction in inflammasome activation and proinflammatory cytokine production as compared to wild type (de Rivero Vaccari et al., 2012), supporting the involvement of purinergic receptor P2X4 in the activation of the NLRP1 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Spinal cord injury can activate the NLRP1 inflammasome to produce IL-1β in rat spinal cord neurons (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Spinal cord injury causes IL-18 and IL-1β release from neuronal cells through the activation of the NLRP1 inflammasome, composed of receptor NLRP1, adaptor protein ASC, caspase-1, caspase-11 and X-linked inhibitor of apoptosis protein (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

Out-Edges 16

complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

Recently, Kaushal et al. described the involvement of NLRP1 inflammasome activation in neurons. In these experiments, serum deprivation induced NLRP1-dependent caspase-1 activity and ASC speck formation, which resulted in caspase-6 activation and an increase in the Ab42/total Ab ratio (11) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) View Subject | View Object

Recently, Kaushal et al. described the involvement of NLRP1 inflammasome activation in neurons. In these experiments, serum deprivation induced NLRP1-dependent caspase-1 activity and ASC speck formation, which resulted in caspase-6 activation and an increase in the Ab42/total Ab ratio (11) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") View Subject | View Object

Recently, Kaushal et al. described the involvement of NLRP1 inflammasome activation in neurons. In these experiments, serum deprivation induced NLRP1-dependent caspase-1 activity and ASC speck formation, which resulted in caspase-6 activation and an increase in the Ab42/total Ab ratio (11) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Apoptosis signaling subgraph

complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Apoptosis signaling subgraph

complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) View Subject | View Object

In the original description of the inflammasome, human NLRP1 was shown to recruit and to activate an additional inflammatory caspase, namely caspase 5, via its CARD3. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

NLRC4 and NLRP1 can both activate caspase 1 through their CARDs without recruiting ASC; however, the recruitment of ASC greatly enhances the formation of the complex and the processing of IL-1β7,13–16. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:CASP4) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:XIAP) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

In the CNS, the production of IL-1β by inflammasomes, specifically NLRP1, NLRP2, NLRP3 and NLRC4, is well-characterized as compared to other interleukins (Minkiewicz et al., 2013; Trendelenburg, 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Central Nervous System
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) View Subject | View Object

Spinal cord injury can activate the NLRP1 inflammasome to produce IL-1β in rat spinal cord neurons (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) View Subject | View Object

Spinal cord injury causes IL-18 and IL-1β release from neuronal cells through the activation of the NLRP1 inflammasome, composed of receptor NLRP1, adaptor protein ASC, caspase-1, caspase-11 and X-linked inhibitor of apoptosis protein (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) View Subject | View Object

Spinal cord injury causes IL-18 and IL-1β release from neuronal cells through the activation of the NLRP1 inflammasome, composed of receptor NLRP1, adaptor protein ASC, caspase-1, caspase-11 and X-linked inhibitor of apoptosis protein (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:CASP1) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.