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complex(GO:"IPAF inflammasome complex")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
IPAF inflammasome complex
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 9

composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) hasComponent complex(GO:"IPAF inflammasome complex") View Subject | View Object

Appears in Networks:

act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") View Subject | View Object

In mice, NAIP (NLR family, apoptosis inhibitory protein) family proteins sense the proteinaceous NLRC4 activators and, in turn, activate the assembly of the NLRC4 inflammasome. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") View Subject | View Object

Palmitate, a fatty acid, activates the NLRC4 inflammasome in primary astrocytes leading to the release of IL-1β (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Recently we identify that palmitate activates the NLRC4 inflammasome in primary astrocytes to release IL-1β, and ASC participates in the activation of the NLRC4 inflammasome (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Under certain but not all conditions ASC (Martinon et al., 2009) or Naip5 (NLR family, apoptosis inhibitory protein 5) (Lightfield et al., 2011) is required for the activity of the NLRC4 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

The adaptor protein ASC is important for the activation of NLRC4 inflammasome in astrocytes, while Naip 5 is not (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Recently we identify that palmitate activates the NLRC4 inflammasome in primary astrocytes to release IL-1β, and ASC participates in the activation of the NLRC4 inflammasome (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Under certain but not all conditions ASC (Martinon et al., 2009) or Naip5 (NLR family, apoptosis inhibitory protein 5) (Lightfield et al., 2011) is required for the activity of the NLRC4 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

Out-Edges 6

complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

NLRC4 and NLRP1 can both activate caspase 1 through their CARDs without recruiting ASC; however, the recruitment of ASC greatly enhances the formation of the complex and the processing of IL-1β7,13–16. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

In the CNS, the production of IL-1β by inflammasomes, specifically NLRP1, NLRP2, NLRP3 and NLRC4, is well-characterized as compared to other interleukins (Minkiewicz et al., 2013; Trendelenburg, 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Central Nervous System
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) View Subject | View Object

Palmitate, a fatty acid, activates the NLRC4 inflammasome in primary astrocytes leading to the release of IL-1β (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) View Subject | View Object

Recently we identify that palmitate activates the NLRC4 inflammasome in primary astrocytes to release IL-1β, and ASC participates in the activation of the NLRC4 inflammasome (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

These studies highlighted the role of saturated fatty acids in the production of IL-1β by inflammasomes, i.e. NLRC4 PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.