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a(CHEBI:Trolox)

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Entity

Name
Trolox
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) hasComponent a(CHEBI:Trolox) View Subject | View Object

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Out-Edges 3

a(CHEBI:Trolox) decreases bp(GO:"cell proliferation") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

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Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:Trolox) decreases bp(GO:"cell migration") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

Appears in Networks:
Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:Trolox) decreases bp(MESH:"Lipid Peroxidation") View Subject | View Object

In contrast, at an equal antioxidant concentration, Trolox completely blocked heme-triggered lipid peroxidation (measured as production of thiobarbituric acid reactive substances (TBARS)) in soybean lecithin micelles (Figure 7g). PubMed:25301065

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.