1. Catalog
  2. Nodes
  3. bp(MESH:"Erythrocyte Aggregation")

bp(MESH:"Erythrocyte Aggregation")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Erythrocyte Aggregation
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

a(CHEBI:"zinc(2+)") increases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

Stimulation with 20 mM Zn2þ resulted in aggregation of washed human erythrocytes 1 h after incubation. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"zinc(2+)") increases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

Thus focusing on Zn2þ-stimulated erythrocytes might be an important new approach that could ultimately reveal the mechanism of immunothrombus formation in sepsis. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(HM:"shear stress") positiveCorrelation bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

At low shear rates or with stasis of blood, RBCs tend to form linear arrays of stacked cells (roleaux) or three-dimensional aggregates [16]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

a(HM:Immunothrombosis) positiveCorrelation bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Introduction

a(MESH:Fibrinogen) increases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

p(HGNC:ALB) causesNoChange bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:ALB) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:ANXA5) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

Annexin V (100 nM) completely inhibited the Zn2þ-induced aggregation (Fig. 1E). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

path(MESH:Thrombosis) positiveCorrelation bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

Out-Edges 8

bp(MESH:"Erythrocyte Aggregation") decreases bp(MESH:"Blood Viscosity") View Subject | View Object

Another consequence of the axial RBC accumulation followed by reduction in local viscosity is a decrease of the wall shear stress causing a lesser local release of nitric oxide [15]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") increases bp(MESH:"Blood Viscosity") View Subject | View Object

Such aggregates are difficult to disperse and they tend to increase the blood viscosity and hydrodynamic resistance in larger blood vessels with low shear, such as the veins in the lower limbs. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") decreases a(CHEBI:"nitric oxide") View Subject | View Object

Another consequence of the axial RBC accumulation followed by reduction in local viscosity is a decrease of the wall shear stress causing a lesser local release of nitric oxide [15]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") positiveCorrelation a(HM:"shear stress") View Subject | View Object

At low shear rates or with stasis of blood, RBCs tend to form linear arrays of stacked cells (roleaux) or three-dimensional aggregates [16]. PubMed:28458720

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") increases path(MESH:Thrombosis) View Subject | View Object

RBC aggregation promotes thrombosis in veins, confirming the pathogenic importance of locally altered blood rheology in the development of venous thrombosis [17]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") increases path(MESH:"Venous Thrombosis") View Subject | View Object

RBC aggregation promotes thrombosis in veins, confirming the pathogenic importance of locally altered blood rheology in the development of venous thrombosis [17]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

bp(MESH:"Erythrocyte Aggregation") positiveCorrelation a(HM:Immunothrombosis) View Subject | View Object

Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.