p(MGI:App, frag("25_35"))

Entity

Name

App

Namespace

mgi

Namespace Version

20181021

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Moreover in Ab-received mice, treatment with PHA and Gal improved the acquisition performance on comparing with the normal saline group (p<0.001) PubMed:25881725

Moreover in Ab-received mice, treatment with PHA and Gal improved the acquisition performance on comparing with the normal saline group (p<0.001) PubMed:25881725

Notably, PHA could completely block the Ab-impaired task acquisition and reduce escape-latency to the normal level. Furthermore, the effect of PHA against the Ab-impaired task acquisition could be abolished by the pre-treatment of the a7 nAChR antagonist MLA (p<0.001). It was also noted that blockade of a7 nAChR by MLA in the Gal-treated group resulted in a significant prolongation of the escape-latency on comparing with the Gal group (p<0.001) (Fig. 2). PubMed:25881725

Inter-group analysis showed that Ab increased escape latency in MWM in comparison with normal saline and sham groups (p<0.001). In addition, sham operation did not have a significant effect on escape latency in comparison with the normal saline group (p>0.05). PubMed:25881725

Time spent in target quadrant in probe trials. On the probe trial, there was a statistically significant difference between groups as determined by a one-way ANOVA (F(4,70)=35.21, p<0.001). Post hoc analysis revealed a significant effect of Ab injection on the time spent in the target quadrant, indicating that the Ab decreased the searching time in the target quadrant on comparing with the control (p<0.001). PubMed:25881725

In contrast, brain sections of animals treated with 10-nmol-aged Ab25–35 peptide demonstrated the presence of numerous and distinct extracellular amyloid deposits, widely disseminated throughout the brain (Fig. 5). PubMed:25881725

mRNA levels of a7 nAChR subunit. Relative quantification by using a real-time RT-PCR did not reveal any significant differences in the levels of mRNA for the a7 nAChR subunits either in the hippocampus or in the cortex of various groups (p>0.05). The groups showed results in the cortex (data not shown) similar to those observed in the hippocampus (Fig. 6). PubMed:25881725