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a(HBP:"4-OH-GTS-21")

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Entity

Name
4-OH-GTS-21
Namespace
HBP
Namespace Version
20181212
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/56d6631d06deeead416b3b5100d3b4b8d88c29c6/export/hbp-names.belns

Appears in Networks 2

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0

In-Edges 0

Out-Edges 10

a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") View Subject | View Object

Whilst the spatial memory deficit was restored by 4OH-GTS-21 treatment, this molecule had no effect on neuronal density (Ren et al., 2007) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") View Subject | View Object

Whilst the spatial memory deficit was restored by 4OH-GTS-21 treatment, this molecule had no effect on neuronal density (Ren et al., 2007) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) View Subject | View Object

4OH-GTS-21 had no effect on the latency to enter the dark chamber during avoidance training (Fig. 1 ) or on swim speed in the Morris water task (data not shown), indicating that it had no discernible effect on locomotor function PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") View Subject | View Object

Treatment with 4OH-GTS-21 improved performance in both of these paradigms, with drug-induced improvements seen at a lower dose (0.3 mg/kg) in avoidance behavior than in the spatial memory–related task PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") View Subject | View Object

Improved performance was seen each day in the Morris water task at the 2 mg/kg drug dose compared with saline-injected, lesioned animals PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) View Subject | View Object

FFX lesions also reduced the size of the septal cholinergic perikarya in saline-injected wild type mice in a manner that was largely prevented by treatment with 4OH-GTS-21 (Fig. 5) PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") View Subject | View Object

4OH-GTS-21 had no effect on cholinergic cell size in the unlesioned sides of the septa of the wild type or PS1 mice, but did cause atrophy of these neurons in the APP/PS1 mice PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") View Subject | View Object

4OH-GTS-21 had no effect on cholinergic cell size in the unlesioned sides of the septa of the wild type or PS1 mice, but did cause atrophy of these neurons in the APP/PS1 mice PubMed:17640819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") View Subject | View Object

4OH-GTS-21 had no protective effect on GABAergic neuronal number in this strain, with FFX lesions causing a 34±9% reduction compared with contralateral controls (n=10; P<0.05 compared with unlesioned side, one-way ANOVA). PubMed:17640819

Appears in Networks:

a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") View Subject | View Object

The density of this deposition was not affected by 2 weeks of twice per day injections of 1 mg/kg 4OH-GTS-21 (275 deposits/section) or by FFX lesions (37±0.4 deposits/section) PubMed:17640819

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.