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Schizophrenia

Name
Schizophrenia
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

While it is not yet possible to know precisely how well a7 nAChRs are activated by smoked nicotine, one can reasonably hypothesize that the patients’ higher dose of nicotine activates alpha7 nAChRs (Adler et al., 1993; Papke and Thinschmidt, 1998; Royal College of Physicians, 2007) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) View Subject | View Object

Yet some of the other genes identified, such as NRG1, are involved in the assembly of alpha7 nAChRs, further supporting a potential link between alpha7 nAChRs and schizophrenia (Mathew et al., 2007) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) View Subject | View Object

Polymorphisms in the alpha7 5' promoter and in a nearby partial duplication of the gene, FAM7A, are associated with both schizophrenia and the defect in inhibition (Leonard et al., 2002) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) View Subject | View Object

Polymorphisms in the alpha7 5' promoter and in a nearby partial duplication of the gene, FAM7A, are associated with both schizophrenia and the defect in inhibition (Leonard et al., 2002) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

a(HBP:"GTS-21") decreases path(MESH:Anhedonia) View Subject | View Object

Clinical ratings of their negative symptoms, particularly anhedonia (absence of a sense of pleasure) and alogia (poverty of content in their speech), also improve during treatment PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.