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p(MGI:Dyrk1a)

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Entity

Name
Dyrk1a
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 19

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) hasComponent p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:

p(MGI:Dcaf1) association p(MGI:Dyrk1a) View Subject | View Object

Moreover, we found that Hap1 bound Dcaf7 competitively in cytoplasm with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a protein implicated in Down syndrome (DS). Depleting Hap1 promoted the DYRK1A-Dcaf7 interaction and increased the DYRK1A protein level. PubMed:28137862

Appears in Networks:

p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Moreover, we found that Hap1 bound Dcaf7 competitively in cytoplasm with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a protein implicated in Down syndrome (DS). Depleting Hap1 promoted the DYRK1A-Dcaf7 interaction and increased the DYRK1A protein level. PubMed:28137862

Appears in Networks:

p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) View Subject | View Object

Here we demonstrated that MEF2D could upregulate DYRK1A gene expression through specific activation of DYRK1A isoform 5 gene transcription. The coordinated expression of DYRK1A and MEF2D in mouse brain development indicated a possibility of the cross-interaction of these two genes during neurodevelopment. The DYRK1A kinase activity was also affected by MEF2D's transcriptional regulation of DYRK1A. PubMed:28775333

Appears in Networks:

path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Out-Edges 20

p(MGI:Dyrk1a) association p(MGI:Dcaf1) View Subject | View Object

Moreover, we found that Hap1 bound Dcaf7 competitively in cytoplasm with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a protein implicated in Down syndrome (DS). Depleting Hap1 promoted the DYRK1A-Dcaf7 interaction and increased the DYRK1A protein level. PubMed:28137862

Appears in Networks:

p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) View Subject | View Object

Appears in Networks:

p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) View Subject | View Object

Moreover, we found that Hap1 bound Dcaf7 competitively in cytoplasm with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a protein implicated in Down syndrome (DS). Depleting Hap1 promoted the DYRK1A-Dcaf7 interaction and increased the DYRK1A protein level. PubMed:28137862

Appears in Networks:

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") View Subject | View Object

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization. PubMed:29221819

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) View Subject | View Object

DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus. PubMed:28540658

Appears in Networks:
Annotations
Uberon
dorsal plus ventral thalamus
Uberon
hippocampal formation
Uberon
hypothalamus
Uberon
striatum

p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) View Subject | View Object

DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus. PubMed:28540658

Appears in Networks:
Annotations
Uberon
hypothalamus

p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) View Subject | View Object

DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus. PubMed:28540658

Appears in Networks:
Annotations
Uberon
hypothalamus

p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.