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p(HBP:"3R tau")

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Entity

Name
3R tau
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 5

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer’s Disease v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 16

path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

On the other side, sarkosyl extracts from the filaments of PSP [129], corticobasal degeneration (CBD; [130]), argyrophilic grain disease (AgD; [131]), and some cases of FTDP-17, contain tau protein that separates as doublets of 64 and 69 kDa and are predominantly composed of tau isoforms with 4R (class II tauopathies), whereas sarkosyl extracts from filaments of Pick’s disease are characterized by the presence of pathological tau doublets of 60 and 64 kDa and contain mainly 3R tau isoforms (class III tauopathy). PubMed:26751493

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p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") View Subject | View Object

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p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") View Subject | View Object

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p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") View Subject | View Object

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p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") View Subject | View Object

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p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") View Subject | View Object

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a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Alzheimer's disease

complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau") View Subject | View Object

However, there are also other mutations (such as ΔK280, L266V and G272V) that inhibit the inclusion of E10 and thus reduce the 4R-to-3R ratio PubMed:26631930

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complex(a(GO:microtubule), p(HBP:"3R tau")) hasComponent p(HBP:"3R tau") View Subject | View Object

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p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau") View Subject | View Object

However, there are also other mutations (such as ΔK280, L266V and G272V) that inhibit the inclusion of E10 and thus reduce the 4R-to-3R ratio PubMed:26631930

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p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau") View Subject | View Object

However, there are also other mutations (such as ΔK280, L266V and G272V) that inhibit the inclusion of E10 and thus reduce the 4R-to-3R ratio PubMed:26631930

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Tauopathies can be classified into three groups on the basis of the tau isoforms found in the aggregates: 4R tauopathies (including PSP, CBD and AGD), 3R tauopathies (for example, PiD) and 3R+4R tauopathies (for example, AD) PubMed:26631930

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path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Tauopathies can be classified into three groups on the basis of the tau isoforms found in the aggregates: 4R tauopathies (including PSP, CBD and AGD), 3R tauopathies (for example, PiD) and 3R+4R tauopathies (for example, AD) PubMed:26631930

Appears in Networks:

Out-Edges 20

p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") View Subject | View Object

On the other side, sarkosyl extracts from the filaments of PSP [129], corticobasal degeneration (CBD; [130]), argyrophilic grain disease (AgD; [131]), and some cases of FTDP-17, contain tau protein that separates as doublets of 64 and 69 kDa and are predominantly composed of tau isoforms with 4R (class II tauopathies), whereas sarkosyl extracts from filaments of Pick’s disease are characterized by the presence of pathological tau doublets of 60 and 64 kDa and contain mainly 3R tau isoforms (class III tauopathy). PubMed:26751493

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p(HBP:"3R tau") isA p(HGNC:MAPT) View Subject | View Object

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p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"ghost tangles") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") View Subject | View Object

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p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") View Subject | View Object

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p(HBP:"3R tau") partOf complex(GO:dendrite) View Subject | View Object

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p(HBP:"3R tau") partOf a(MESH:Neuropil) View Subject | View Object

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p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") View Subject | View Object

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p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"3R tau") increases a(HBP:"straight filaments") View Subject | View Object

For the sake of completeness, we also refer to tau- 3R transgenic mice that developed another type of pathology in the hippocampus, e.g., straight fila- ments formed in aged mice older than 18 mo (Ishi- hara, 2001b), which was proposed to be relevant for AD, given the age-dependence. PubMed:12428809

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p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") View Subject | View Object

Tauopathies can be classified into three groups on the basis of the tau isoforms found in the aggregates: 4R tauopathies (including PSP, CBD and AGD), 3R tauopathies (for example, PiD) and 3R+4R tauopathies (for example, AD) PubMed:26631930

Appears in Networks:

p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Tauopathies can be classified into three groups on the basis of the tau isoforms found in the aggregates: 4R tauopathies (including PSP, CBD and AGD), 3R tauopathies (for example, PiD) and 3R+4R tauopathies (for example, AD) PubMed:26631930

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p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau")) View Subject | View Object

Owing to the additional repeat domain R2, 4R tau shows higher affinity for microtubules than does 3R tau, and is therefore more efficient at promoting microtubule assembly PubMed:26631930

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.