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striatum

Name
striatum
Namespace Keyword
Anatomy
Namespace
Uberon
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno

Sample Annotated Edges 5

p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) View Subject | View Object

In PSP cases, both coiled bodies (Fig. 2 D-F) and NFTs (Fig. 2G-I) in the striatum showed a complete co-localisation of PICALM and phosphotau immunoreactivies. PubMed:27260836

Appears in Networks:
Annotations
Uberon
striatum
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

In PSP cases, both coiled bodies (Fig. 2 D-F) and NFTs (Fig. 2G-I) in the striatum showed a complete co-localisation of PICALM and phosphotau immunoreactivies. PubMed:27260836

Appears in Networks:
Annotations
Uberon
striatum
Disease Ontology (DO)
progressive supranuclear palsy

a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) View Subject | View Object

Alsterpaullone, the most active paullone, was demonstrated to act by competing with ATP for binding to GSK-3beta. Alsterpaullone inhibits the phosphorylation of tau in vivo at sites which are typically phosphorylated by GSK-3beta in Alzheimer's disease. Alsterpaullone also inhibits the CDK5/p25-dependent phosphorylation of DARPP-32 in mouse striatum slices in vitro. PubMed:10998059

Appears in Networks:
Annotations
Uberon
striatum

a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) View Subject | View Object

Alsterpaullone, the most active paullone, was demonstrated to act by competing with ATP for binding to GSK-3beta. Alsterpaullone inhibits the phosphorylation of tau in vivo at sites which are typically phosphorylated by GSK-3beta in Alzheimer's disease. Alsterpaullone also inhibits the CDK5/p25-dependent phosphorylation of DARPP-32 in mouse striatum slices in vitro. PubMed:10998059

Appears in Networks:
Annotations
Uberon
striatum

p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) View Subject | View Object

DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus. PubMed:28540658

Appears in Networks:
Annotations
Uberon
dorsal plus ventral thalamus
Uberon
hippocampal formation
Uberon
hypothalamus
Uberon
striatum

Showing 5 of 6 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.