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p(MGI:App)

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Entity

Name
App
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 8

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus v1.0.0

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0

Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

In-Edges 2

composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) hasComponent p(MGI:App) View Subject | View Object

Appears in Networks:

p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Out-Edges 7

p(MGI:App) hasVariant p(MGI:App, var("?")) View Subject | View Object

Appears in Networks:

p(MGI:App) hasVariant p(MGI:App, frag("25_35")) View Subject | View Object

Appears in Networks:

p(MGI:App) hasVariant p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) View Subject | View Object

Appears in Networks:

p(MGI:App) hasVariant p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) View Subject | View Object

Appears in Networks:

p(MGI:App) hasVariant p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")) View Subject | View Object

Appears in Networks:

p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:App) hasVariant p(MGI:App, frag("1_38")) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.