p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202))

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PubMed:29221819

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum.

Related Edges 11

• a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a)
• act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a)
• bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a)
• p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a)
• p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence")
• p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron"))
• p(MGI:Dyrk1a) negativeCorrelation p(MGI:App)
• p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta")
• p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt)
• p(MGI:App) negativeCorrelation p(MGI:Dyrk1a)
• p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a)

Uberon

cerebellum

Uberon

hippocampal formation

MeSH

Alzheimer Disease

MeSH

Down Syndrome

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