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bp(GO:"cellular senescence")

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Entity

Name
cellular senescence
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 13

a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") View Subject | View Object

Collectively, these findings indicate a strong association between the presence of NFTs and cellular senescence in the brain, which contributes to neurodegeneration PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cell cycle") association bp(GO:"cellular senescence") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"inflammatory response") association bp(GO:"cellular senescence") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") View Subject | View Object

The cell cycle protein p21, encoded by Cdkn1a, is upregulated in many senescent cell types and has been associated with DNA damage during neuronal aging (Jurk et al., 2012) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") View Subject | View Object

Relative to the existing neuronal population at this advanced age, gene expression of the NFT-associated senescence gene array was reduced by DQ (P = 0.0006; Figure S6a) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") View Subject | View Object

The astrocyte protein GFAP was unchanged, while microglia Iba1 expression was elevated (Iba1: 40%, P = 0.0013; Figure S6b-d) suggesting that DQ-mediated neuroprotection and decreased SASP was not derived from a reduction in pro-inflammatory glia (astrocytes or microglia) but instead associated with fewer NFT-containing neurons PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(MGI:Cdkn2a) association bp(GO:"cellular senescence") View Subject | View Object

Cdkn2a transcript level, a hallmark measure of senescence, directly correlated with brain atrophy and NFT burden in mice PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") View Subject | View Object

TauNFT mouse brains displayed significantly elevated histone γ-H2ax, a sensitive marker of both double-stranded DNA breaks and cellular senescence (Sedelnikova et al., 2004) (P = 0.0056; Figure 1d-e) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

p(MGI:Mapt) increases bp(GO:"cellular senescence") View Subject | View Object

The reduced tau pathology corresponded with 60% lower Cdkn2a expression (P = 0.0041, Figure 4a), decreased SASP (Figure S4) and decreased brain atrophy (tauNFT-Mapt0/0: 0.4058 ± 0.009 versus age-matched tauNFT Maptwt/wt: 0.3451 ± 0.0116; 17.5% difference, P = 0.0143, Figure 4b) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") View Subject | View Object

TauNFT mice develop aggressive tauopathy with NFT formation in early life, and show a senescence-associated transcriptomic profile with NFT onset (Figure 1c) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

path(MESH:Tauopathies) association bp(GO:"cellular senescence") View Subject | View Object

Experimental data from various studies indicate that tau pathology may be associated with cellular senescence, a fundamental aging mechanism shown to contribute to several chronic diseases (recent review Kirkland and Tchkonia, 2017) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Alzheimer Disease

p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Out-Edges 25

bp(GO:"cellular senescence") increases bp(HBP:HBP00037) View Subject | View Object

Mitochondrial dysfunction is obligatory for SASP production and cellular senescence (Correia-Melo et al., 2016; Hutter et al., 2004) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association bp(GO:"cell cycle") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association p(MGI:Cdkn2a) View Subject | View Object

Cdkn2a transcript level, a hallmark measure of senescence, directly correlated with brain atrophy and NFT burden in mice PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") View Subject | View Object

Tau transgenic mice with late stage pathology were treated with senolytics to remove senescent cells. Despite the advanced age and disease progression, MRI brain imaging and histopathological analyses indicated a reduction in total NFT density, neuron loss and ventricular enlargement PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") View Subject | View Object

Collectively, these findings indicate a strong association between the presence of NFTs and cellular senescence in the brain, which contributes to neurodegeneration PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(GO:"neuron death") View Subject | View Object

Tau transgenic mice with late stage pathology were treated with senolytics to remove senescent cells. Despite the advanced age and disease progression, MRI brain imaging and histopathological analyses indicated a reduction in total NFT density, neuron loss and ventricular enlargement PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") View Subject | View Object

Tau transgenic mice with late stage pathology were treated with senolytics to remove senescent cells. Despite the advanced age and disease progression, MRI brain imaging and histopathological analyses indicated a reduction in total NFT density, neuron loss and ventricular enlargement PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") View Subject | View Object

Tau transgenic mice with late stage pathology were treated with senolytics to remove senescent cells. Despite the advanced age and disease progression, MRI brain imaging and histopathological analyses indicated a reduction in total NFT density, neuron loss and ventricular enlargement PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) View Subject | View Object

Collectively, these findings indicate a strong association between the presence of NFTs and cellular senescence in the brain, which contributes to neurodegeneration PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association path(MESH:Tauopathies) View Subject | View Object

Experimental data from various studies indicate that tau pathology may be associated with cellular senescence, a fundamental aging mechanism shown to contribute to several chronic diseases (recent review Kirkland and Tchkonia, 2017) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") View Subject | View Object

Senescence-inducing stressors often inflict DNA-damage that drives production of the SASP (Rodier et al., 2009) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") View Subject | View Object

The cell cycle protein p21, encoded by Cdkn1a, is upregulated in many senescent cell types and has been associated with DNA damage during neuronal aging (Jurk et al., 2012) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) View Subject | View Object

The cell cycle protein p21, encoded by Cdkn1a, is upregulated in many senescent cell types and has been associated with DNA damage during neuronal aging (Jurk et al., 2012) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) View Subject | View Object

Similarly, elevated expression of the cyclin dependent kinase inhibitor 2a, Cdkn2a, is one of the most robust markers of cellular senescence, and its protein product, p16INK4A, co-localizes with NFTs in human AD (Arendt et al., 1996) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") association bp(GO:"inflammatory response") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. PubMed:29221819

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

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