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p(HGNC:SYK, pmod(Ph))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SYK
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) View Subject | View Object

We found an increase in Syk activation in DNs surrounding Aβ deposits as well as in neurons displaying an accumulation of phosphorylated Tau at Y18 and elevated levels of MC1 pathogenic tau conformers in AD brain sections whereas only weak immunoreactivity for pSyk was observed in brain sections from a non-demented control PubMed:28877763

Appears in Networks:

p(HGNC:SYK) hasVariant p(HGNC:SYK, pmod(Ph)) View Subject | View Object

Appears in Networks:

path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) View Subject | View Object

We found an increase in Syk activation in DNs surrounding Aβ deposits as well as in neurons displaying an accumulation of phosphorylated Tau at Y18 and elevated levels of MC1 pathogenic tau conformers in AD brain sections whereas only weak immunoreactivity for pSyk was observed in brain sections from a non-demented control PubMed:28877763

Appears in Networks:

a(CHEBI:heme) increases p(HGNC:SYK, pmod(Ph)) View Subject | View Object

Heme induces Syk phosphorylation in macrophages. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

Out-Edges 2

p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") View Subject | View Object

We found an increase in Syk activation in DNs surrounding Aβ deposits as well as in neurons displaying an accumulation of phosphorylated Tau at Y18 and elevated levels of MC1 pathogenic tau conformers in AD brain sections whereas only weak immunoreactivity for pSyk was observed in brain sections from a non-demented control PubMed:28877763

Appears in Networks:

p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) View Subject | View Object

We found an increase in Syk activation in DNs surrounding Aβ deposits as well as in neurons displaying an accumulation of phosphorylated Tau at Y18 and elevated levels of MC1 pathogenic tau conformers in AD brain sections whereas only weak immunoreactivity for pSyk was observed in brain sections from a non-demented control PubMed:28877763

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.