a(CHEBI:"leukotriene B4")
. Heme activates macrophages inducing the production of TNF, KC (Figueiredo et al., 2007), IL-1β (unpublished), and LTB4 (Monteiro et al., 2011). PubMed:24904418
In fact, heme can induce neutrophil migration by acting as a chemotactic molecule (Porto et al., 2007) or by inducing the production of leukotriene B4 (LTB4) by macrophages (Monteiro et al., 2011). PubMed:24904418
As described before, LTB4 has an important function regulating heme-induced neutrophils migration (Monteiro et al., 2011). PubMed:24904418
KC (keratinocyte-derived chemokine) is a chemokine that attracts neutrophils to sites of inflammation and LTB4 is a lipid mediator that functions as a chemoattractant molecule and also activates leukocytes. PubMed:24904418
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