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path(MESH:"Anemia, Sickle Cell")

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Entity

Name
Anemia, Sickle Cell
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:heme) positiveCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

The consequences of heme toxicity can be appreciated in hemolytic diseases such as β-thalassemia, sickle-cell disease (SCD), ischemia-reperfusion (IR), and malaria (Katori et al., 2002; Pamplona et al., 2007;Vinchi et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

a(HM:"erythrocyte-endothelium adhesion") positiveCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

The most common pathological states in which RBCs interact with the endothelium include sickle cell disease [39], malaria [40], and diabetes [41]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

p(HGNC:HPX) negativeCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

Studies of sickle cell anemia patients have reported decreased levels of Hpx following hemolysis [68]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

SCD and β-thalassemia are genetic diseases associated to erythrocytes that are prone to lysis due to defective Hb production (Heinle and Read, 1948; Pauling et al., 1949; Ingram, 1957; discussed later). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Rhabdomyolysis
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

Hemolysis can happen due to ischemia/reperfusion, SCD or β-thalassemia. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Anemia, Sickle Cell") View Subject | View Object

SCD is a haemolytic disorder caused by a HBB (b-globin gene) mutation leading to polymerization of haemoglobin S, sickling, and haemolysis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Review

path(MESH:Thrombosis) association path(MESH:"Anemia, Sickle Cell") View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

Out-Edges 12

path(MESH:"Anemia, Sickle Cell") positiveCorrelation a(CHEBI:heme) View Subject | View Object

The consequences of heme toxicity can be appreciated in hemolytic diseases such as β-thalassemia, sickle-cell disease (SCD), ischemia-reperfusion (IR), and malaria (Katori et al., 2002; Pamplona et al., 2007;Vinchi et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Anemia, Sickle Cell") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

SCD and β-thalassemia are genetic diseases associated to erythrocytes that are prone to lysis due to defective Hb production (Heinle and Read, 1948; Pauling et al., 1949; Ingram, 1957; discussed later). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Rhabdomyolysis
Text Location
Review

path(MESH:"Anemia, Sickle Cell") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Hemolysis can happen due to ischemia/reperfusion, SCD or β-thalassemia. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:"Anemia, Sickle Cell") increases path(MESH:Hemolysis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

path(MESH:"Anemia, Sickle Cell") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

SCD is a haemolytic disorder caused by a HBB (b-globin gene) mutation leading to polymerization of haemoglobin S, sickling, and haemolysis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Review

path(MESH:"Anemia, Sickle Cell") increases path(MESH:Hemolysis) View Subject | View Object

Systemic hemolysis occurs during certain genetic and acquired anemia, such as in sickle cell disease and malaria. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

path(MESH:"Anemia, Sickle Cell") decreases p(HGNC:HP) View Subject | View Object

Thus, in severe haemolytic diseases, such as paroxysmal nocturnal haemoglobinuria (PNH) and sickle cell disease (SCD), serum haptoglobin is typically undetectable and plasma haemoglobin is elevated (Tabbara, 1992). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

path(MESH:"Anemia, Sickle Cell") increases p(HGNC:HBB) View Subject | View Object

Thus, in severe haemolytic diseases, such as paroxysmal nocturnal haemoglobinuria (PNH) and sickle cell disease (SCD), serum haptoglobin is typically undetectable and plasma haemoglobin is elevated (Tabbara, 1992). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

path(MESH:"Anemia, Sickle Cell") association path(MESH:Thrombosis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

path(MESH:"Anemia, Sickle Cell") negativeCorrelation p(HGNC:HPX) View Subject | View Object

Studies of sickle cell anemia patients have reported decreased levels of Hpx following hemolysis [68]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

path(MESH:"Anemia, Sickle Cell") positiveCorrelation a(HM:"erythrocyte-endothelium adhesion") View Subject | View Object

The most common pathological states in which RBCs interact with the endothelium include sickle cell disease [39], malaria [40], and diabetes [41]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

path(MESH:"Anemia, Sickle Cell") increases bp(MESH:"Regional Blood Flow") View Subject | View Object

The preferential adaptive increase in cerebral blood flow has also been demonstrated in other models of anemia, including acute hemodilution and chronic sickle cell anemia (3, 41). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Cerebrum
MeSH
Anemia
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.