Cerebrum
Cerebral levels of IDE are reduced in early AD and in mouse models of AD, whereas, mirroring AD amyloidosis, Aβ42 accumulates in mice genetically depleted of IDE. PubMed:30116051
The preferential adaptive increase in cerebral blood flow has also been demonstrated in other models of anemia, including acute hemodilution and chronic sickle cell anemia (3, 41). PubMed:29351418
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