The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0||33%|
|Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0||30%|
|Effects of peptides derived from BACE1 catalytic domain on APP processing v1.0.0||30%|
|Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1||28%|
|Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0||25%|
|Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0||25%|
|Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0||20%|
|Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0||20%|
|Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0||19%|
|Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0||18%|
Given the size of AD-related proteins, mono- meric Aβ1-40, Aβ1-42 and tau, should be able to pass freely through astrocytic endfeet clefts at the glial barrier.72
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.