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Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:36:32.856628
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
61
Number Edges
83
Number Components
2
Network Density
0.0226775956284153
Average Degree
1.36065573770492
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0 21%
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor v1.0.0 17%
Silencing of PMT expression caused a surge of anatabine accumulation in tobacco v1.0.0 15%
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0 15%
albuquerque2009 v1.0.0 15%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 15%
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0 15%
Anatabine ameliorates experimental autoimmune thyroiditis. v1.0.0 13%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 13%
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0 13%

Sample Edges

a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) View Subject | View Object

Lobeline binds with high affinity to α4β2 nAChRs and displays mixed receptor agonist/antagonist actions (e.g., [150–154]). PubMed:28391535

a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) View Subject | View Object

Lobeline has, however, been shown to antagonize partially the stimulus effects of (-)-nicotine and S(+)-methamphetamine ([64, 160]; but see [66]). PubMed:28391535

a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:methamphetamine)) View Subject | View Object

Lobeline has, however, been shown to antagonize partially the stimulus effects of (-)-nicotine and S(+)-methamphetamine ([64, 160]; but see [66]). PubMed:28391535

a(CHEBI:"(R)-nicotine") increases path(MESH:Death) View Subject | View Object

In comparison, S(-)-nicotine was shown to be 7 times more toxic than R(+)-nicotine in rats injected intravenously PubMed:28391535

a(CHEBI:"(S)-nicotine") increases path(MESH:Death) View Subject | View Object

In comparison, S(-)-nicotine was shown to be 7 times more toxic than R(+)-nicotine in rats injected intravenously PubMed:28391535

Sample Nodes

bp(GO:"cellular respiration")

In-Edges: 6 | Out-Edges: 3 | Explore Neighborhood | Download JSON

bp(GO:cognition)

In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON

path(MESH:Smoking)

In-Edges: 4 | Out-Edges: 6 | Explore Neighborhood | Download JSON

a(CHEBI:bupropion)

In-Edges: 1 | Out-Edges: 7 | Explore Neighborhood | Download JSON

a(CHEBI:dopamine)

In-Edges: 46 | Out-Edges: 13 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.