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p(HGNC:PPP2R1A)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPP2R1A
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

Assembly and structure of protein phosphatase 2A v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 24

p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) View Subject | View Object

The scaffold subunit of PP2A contains 15 tandem repeats of a conserved 39-amino-acid sequence known as a HEAT (huntingtin-elongation-A subunit-TOR) motif PubMed:19277525

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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p(FPLX:"PPP2R_A") hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(GO:"protein phosphatase type 2A complex") hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

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Out-Edges 10

act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) View Subject | View Object

Second, conformational flexibility of the scaffold subunit might be important for the phosphatase activity of the catalytic subunit PubMed:19277525

Appears in Networks:

p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") View Subject | View Object

The scaffold subunit of PP2A contains 15 tandem repeats of a conserved 39-amino-acid sequence known as a HEAT (huntingtin-elongation-A subunit-TOR) motif PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

Appears in Networks:

act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) View Subject | View Object

First, conformational flexibility of the scaffold subunit is required for binding to the catalytic subunit and possibly other interacting proteins such as the regulatory subunits. PubMed:19277525

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p(HGNC:PPP2R1A) hasVariant p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.